Abstract
In this study, a series of novel silicon (IV) phthalocyanines conjugated axially with anti-inflammatory (sulindac) and triethylene glycol groups has been synthesized. Different synthetic strategies were attempted to obtain the targeted molecules in high yield. The compounds were fully characterized by using different analyses techniques. Our objectives were to generate a system with sulindac group which enhances the singlet oxygen generation and exhibits anti-cancer effect. Therefore, photophysical and photochemical properties of these compounds were investigated in different solvents. The substituent effect on fluorescence quantum yield and singlet oxygen generation was evaluated for efficiency in photodynamic therapy (PDT) as photosensitizer. The molecules exhibited no aggregation tendency, solubility in common organic solvents, high singlet oxygen quantum yield and high photostability in DMSO so these favourable properties make them good candidates as photosensitizer for PDT. In addition, their stabilities were investigated in DMSO, THF, acetonitrile and DMF.
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References
Detty MR, Gibson SL, Wagner SJ (2004) Current clinical and preclinical photosensitizers for use in photodynamic therapy. J Med Chem 47(16):3897–3915
Plaetzer K, Krammer B, Berlanda J, Berr F, Kiesslich T (2009) Photophysics and photochemistry of photodynamic therapy: fundamental aspects. Lasers Med Sci 24:259–268
Robertson CA, Evans DH, Abrahamse H (2009) Photodynamic therapy (PDT): a short review on cellular mechanisms and cancer research applications for PDT. J Photochem Photobiol B 96(1):1–8
Allison RR, Sibata CH (2010) Oncologic photodynamic therapy photosensitizers: a clinical review. Photodiagn Photodyn Ther 7:61–75
Asem H, El-Fettah A, Nafee N, Zhao Y, Khalil L, Mamoun M, Moustapha H, Kandil S (2016) Development and biodistribution of a theranostic aluminum phthalocyanine nanophotosensitizer. Photodiagn Photodyn Ther 13:48–57
Dumoulin F, Durmuş M, Ahsen V, Nyokong T (2010) Synthetic pathways to water-soluble phthalocyanines and close analogs. Coord Chem Rev 254:2792–2847
Tabata K, Fukushima K, Oda K, Okura I (2006) Selective aggregation of zinc phthalocyanines in the skin. J Porphyrins Phthalocyanines 10:1116–1124
Allen CM, Sharman WM, Van Lier JE (2001) Current status of phthalocyanines in the photodynamic therapy of cancer. J Porphyrins Phthalocyanines 5:161–169
Jiang XJ, Huang JD, Zhu YJ, Tang FX, Ng KPD (2006) Preparation and in vitro photodynamic activities of novel axially substituted silicon (IV) phthalocyanines and their bovine serum albumin conjugates. Bioorg Med Chem Letters 16:2450–2453
Evren D, Özçeşmeci İ, Sesalan BŞ, Burat KA (2013) Investigation of the biological properties of water soluble quinoline substituted phthalocyanines. Synth Met 168:31–35
Lochman L, Svec J, Roh J, Novakova V (2015) The role of the size of aza-crown recognition moiety in azaphthalocyanine fluorescence sensors for alkali and alkaline earth metal cations. Dyes Pigments 121:178–187
Bankole MO, Britton J, Nyokong T (2015) Photophysical and non-linear optical behavior of novel tetra alkynyl terminated indium phthalocyanines: effects of the carbon chain length. Polyhedron 88:73–80
Sholto A, Ehrenberg B (2008) Hydrophobicity, topography in membranes and photosensitization of siliconphthalocyanines with axial ligands of varying lengths. Photochem Photobiol Sci 7:344–351
Lo PC, Leung SCH, Chan EYM, Fong WP, Ko WH, Ng DKP (2007) Photodynamic effects of a novel series of silicon(IV) phthalocyanines against human colon adenocarcinoma cells. Photodiagn Photodyn Ther 4:117–123
Priscilla PSL, Pui-Chi L, Elaine YMC, Ng KPD (2005) Synthesis and in vitro photodynamic activity of novel galactose-containing phthalocyanines. Tetrahedron Lett 46:1551–1554
Lau JTF, Lo PC, Tsang YM, Fong WP, Ng DKP (2011) Unsymmetrical β-cyclodextrin-conjugated silicon(IV) phthalocyanines as highly potent photosensitisers for photodynamic therapy. Chem Commun 47:9657–9659
Mao J, Zhang Y, Zhu J, Zhang C, Guo Z (2009) Molecular combo of photodynamic therapeutic agent silicon(IV) phthalocyanine and anticancer drug cisplatin. Chem Commun:908–910
Zhu YJ, Huang JD, Jiang XJ (2006) Novel silicon phthalocyanines axially modified by morpholine: synthesis, complexation with serum protein and in vitro photodynamic activity. Inorg Chem Commun 9:473–477
Hofman JW, Zeeland F, Turker S, Talsma H, Lambrechts SAG, Sakharov DV, Hennick WE, Nostrum CF (2007) Peripheral and axial substitution of phthalocyanines with solketal groups: synthesis and in vitro evaluation for photodynamic therapy. J Med Chem 50:1485–1494
Li H, Jensen TJ, Fronczek FR, Vicente GH (2008) Syntheses and properties of a series of cationic water-soluble phthalocyanines. J Med Chem 51:502–511
Anula HM, Berlin JC, Wu H, Li YS, Peng X, Kenney ME, Rodgers MAJ (2006) Synthesis and photophysical properties of silicon phthalocyanines with axial siloxy ligands bearing alkylamine termini. J Phys Chem A 110:5215–5223
Cordoba WR, Noria R, Guarin CA, Peon J (2011) Ultrafast photosensitization of phthalocyanines through their axial ligands. J Am Chem Soc 133:4698–4701
Baron ED, Malbasa CL, Santa Domingo D, Fu P, Miller JD, Hanneman KK, Hsia AH, Oleinick NL, Colussi VC, Cooper KD (2010) Silicon phthalocyanine (pc 4) photodynamic therapy is a safe modality for cutaneous neoplasms: results of a phase 1 clinical trial. Laser Surg Med 42:728–735
Foster TH, Giesselman BR, Hu R, Kenney ME, Mitra S (2007) Intratumor administration of the photosensitizer pc 4 affords photodynamic therapy efficacy and selectivity at short drug-light intervals. Toxicol Appl Pharm 224:290–299
Oleinick NL, Antunez AR, Clay ME, Rihter BD, Kenney ME (1993) New phthalocyanine photosensitizers for photodynamic therapy. J Photochem Photobiol 57:242–247
Conte C, Ungaro F, Maglio G, Tirino P, Siracusano G, Sciortino MT, Leone N, Palma G, Barbieri A, Arra C, Mazzaglia A, Quaglia F (2013) Biodegradable core-shell nanoassemblies for the delivery of docetaxel and Zn(II)-phthalocyanine inspired by combination therapy for cancer. J Control Release 167:40–52
Ma D, Liu Z, Zheng Q, Zhou X, Zhang Y, Shi Y, Lin J, Xue W (2013) Star-shaped polymer consisting of a porphyrin core and poly(L-lysine) dendron arms: synthesis, drug delivery, and in vitro chemo/photodynamic therapy. Macromol Rapid Commun 34:548–552
Kakiuchi Y, Tsuji S, Tsujii M, Murata H, Kawai N, Yasumaru M, Kimura A, Komori M, Irie T, Miyoshi E, Sasaki Y, Hayashi N, Kawano S, Hori M (2002) Cyclooxygenase-2 activity altered the cell-surface carbohydrate antigens on colon cancer cells and enhanced liver metastasis. Cancer Res 62(5):1567–1572
Jones MK, Wang H, Peskar BM, Levin E, Itani RM, Sarfeh IJ, Tarnawski AS (2001) Inhibition of angiogenesis by nonsteroidal anti-inflammatory drugs: insight into mechanisms and implications for cancer growth and ulcer healing. Nat Med 5(12):1418–1423
Souza RF, Shewmake K, Beer DG, Cryer B, Spechler SJ (2000) Selective inhibition of cyclooxygenase-2 suppresses growth and induces apoptosis in human esophageal adenocarcinoma cells. Cancer Res 60(20):5767–5772
DuBois RN, Abramson SB, Crofford L, Gupta RA, Simon LS, van de Putte LB, Lipsky PE (1998) Cyclooxygenase in biology and disease. FASEB J 12:1063–1073
Shiff SJ, Shivaprasad P, Santini DL (2003) Cyclooxygenase inhibitors: drugs for cancerprevention. Curr Opin Pharmacol 3:352–361
Taşkın CG, Durmuş M, Yüksel F, Mantareva V, Kussovski V, Angelov I, Atilla D (2015) Axially paraben substituted silicon(IV) phthalocyanines towards dental pathogen Streptococcus mutans: synthesis, photophysical, photochemical and in vitro properties. J Photochem Photobiol A Chem 306:31–40
Wheeler BL, Nagasubramanian G, Bard AJ, Schechtman LA, Dininny DR, Kenney ME (1984) A silicon phthalocyanine and a silicon naphthalocyanine: synthesis, electrochemistry and electrogenerated chemiluminescence. J Am Chem Soc 106:7404–7410
Sasa N, Okada K, Nakamura K, Okada S (1998) Synthesis, structural and conformational analysis and chemical proporties of phthalocyaninatometal complexes. J Mol Struct 446:163–178
Jacques P, Braun AM (1981) Laser flash photolysis of phthalocyanines in solution and microemulsion. Helv Chim Acta 64:1800–1806
Ogunsipe A, Maree D, Nyokong T (2003) Solvent effects on the photochemical and fluorescence properties of zinc phthalocyanine derivatives. J Mol Struct 650(1–3):131–140
Ogunsipe A, Nyokong T (2005) Photophysical and photochemical studies of sulphonated non-transition metal phthalocyanines in aqueous and non-aqueous media. J Photochem Photobiol A 173(2):211–220
Kuznetsova N, Gretsova N, Kalmkova E, Makarova E, Dashkevich S, Negrimovskii V, Kaliya O, Luk’yanets E (2000) Relationship between the photochemical properties and structure of pophyrins and related compounds. Russ J Gen Chem 70:133–140
Maree MD, Kuznetsova N, Nyokong T (2001) Silicon octaphenoxy phthalocyanines photo stability and singlet oxygen quantum yields. J Photochem Photobiol A Chem 140:117–125
Bıyıklıoglu Z (2013) Water-soluble axially disubstituted non-aggregated silicon phthalocyanines and their electrochemical properties. Dyes Pigments 99:59–66
Shen XM, Jiang XJ, Huang CC, Zhang HH, Huang JD (2010) Highly photostable silicon (IV) phthalocyanines containing adamantane moieties:synthesis, structure, and properties. Tetrahedron 66:9041–9048
Ogunsipe A, Chen J, Nyokong T (2004) Photophysical and photochemical studies of zinc(II) phthalocyanine derivatives—effects of substituents and solvents. New J Chem 28:822–827
İşci Ü, Beyreis M, Tortik N, Topal SZ, Glueck M, Ahsen V, Dumoulin F, Kiesslich T, Plaetze K (2016) Methylsulfonyl Zn phthalocyanine: a polyvalent and powerful hydrophobic photosensitizer with a wide spectrum of photodynamic applications. Photodiagn Photodyn Ther 13:40–47
Semerci F, Yeşilel OZ, Yüksel F (2015) Self-assembly of three new metal organic coordination networks based on 1,2-bis(imidazol-1yl-methyl)benzene. Polyhedron 102:1–7
Wang Y, Cao R, Bi W, Li X, Yuan D (2006) Four novel porous frameworks constructed by formate ligand. Microporous Mesoporous Mater 91:215
Chen XM, Tong ML (2007) Solvothermal in situ metal/ligand reactions: a new bridge between coordination chemistry and organic synthetic chemistry. Acc Chem Res 40(2):162–170
Atmaca GY, Dizman C, Eren T (2015) Novel axially carborane-cage substituted silicon phthalocyanine photosensitizer; synthesis, characterization and photophysicochemical properties. Spectrochimica Acta Part A: Mol Biomol Spect 137:244–249
Uslan C, Oppelt KT, Reith LM, Sesalan BŞ, Knör G (2013) Characterization of a non-aggregating silicon(IV) phthalocyanine in aqueous solution: toward red-light-driven photocatalysis based on earth-abundant materials. Chem Commun 49:8108–8110
Seotsanyana-Mokhosi I, Kuznetsova N, Nyokong T (2001) Photochemical studies of tetra-2,3-pyridinoporphyrazines. J Photochem Photobiol A Chem 140:215–222
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The Scientific and Technological Research Council of Turkey (TUBITAK) is gratefully acknowledged (project 114Z463 coupled to the COST Action CM1106).
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Şahin, B., Topal, S.Z. & Atilla, D. Synthesis, Photophysical and Photochemical Properties of a Set of Silicon Phthalocyanines Bearing Anti-Inflammatory Groups. J Fluoresc 27, 407–416 (2017). https://doi.org/10.1007/s10895-016-1969-y
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DOI: https://doi.org/10.1007/s10895-016-1969-y