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Synthesis, Characterization, DNA Binding, Light Switch “On and Off”, Docking Studies and Cytotoxicity, of Ruthenium(II) and Cobalt(III) Polypyridyl Complexes

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Abstract

The novel ligand (dmbip) 2-(4-N, N-dimethylbenzenamine)1H-imidazo[4, 5-f][1, 10]phenanthroline and its complexes [Ru(phen)2dmbip]2+ (1), [Ru(bpy)2dmbip]2+ (2), [Co(phen)2dmbip]3+ (3) and [Co(bpy)2dmbip]3+ (4) [where phen = 1, 10-phenanthroline, bpy = 2, 2′-bipyridine], have been synthesized and characterized by elemental analysis, IR, UV-Vis, 1H NMR, 13C NMR and Mass spectra. The DNA binding properties of the complexes were investigated by absorption, emission, quenching studies, light switch “on and off”, salt dependent, sensor (cation and anion) studies, viscosity measurements, cyclic voltammetry, molecular modeling and docking studies. The four complexes were screened for Photo cleavage of pBR322 DNA, antimicrobial activity and cytotoxicity. The experimental results indicate that the four complexes can intercalate into DNA base pairs. The DNA-binding affinities of these complexes follow the order [Ru(phen)2dmbip]2+ > [Co(phen)2dmbip]3+ > [Ru(bpy)2dmbip]2+ > [Co(bpy)2dmbip]3+.

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Acknowledgements

We are grateful to DBT, New Delhi for financial support and CFRD, Osmania University, Hyderabad-07, for recording NMR spectra.

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Authors and Affiliations

  1. Department of Chemistry, Osmania University, Hyderabad, 500007, India

    M. Rajender Reddy, Putta Venkat Reddy, Yata Praveen Kumar, A. Srishailam & S. Satyanarayana

  2. Department of Chemistry, Nizam College, Osmania University, Hyderabad, 500007, India

    Navaneetha Nambigari

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  1. M. Rajender Reddy
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  2. Putta Venkat Reddy
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  4. A. Srishailam
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Correspondence to S. Satyanarayana.

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Reddy, M.R., Reddy, P.V., Kumar, Y.P. et al. Synthesis, Characterization, DNA Binding, Light Switch “On and Off”, Docking Studies and Cytotoxicity, of Ruthenium(II) and Cobalt(III) Polypyridyl Complexes. J Fluoresc 24, 803–817 (2014). https://doi.org/10.1007/s10895-014-1355-6

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