Skip to main content
SpringerLink
Log in

A Novel Colorimetric and Off–On Fluorescent Chemosensor for Cr3+ in Aqueous Solution and its Application in Live Cell Imaging

  • ORIGINAL PAPER
  • Published:
Journal of Fluorescence Aims and scope Submit manuscript

Abstract

A novel colorimetric and off–on fluorescent chemosensor 2 was designed and synthesized, which showed reversible and highly selective and sensitive recognition toward Cr3+ over other examined metal ions in aqueous solution. Upon addition of Cr3+, the solution of chemosensor 2 resulted in a color change from colorless to obvious pink color, these significant changes in color could be used for naked-eye detection. Chemosensor 2 exhibited a stable response for Cr3+ in the range 0–10 μM with a detection limit of 1 ppm. Furthermore, fluorescence imaging experiments of Cr3+ ions in living MGC803 cells demonstrated its value of practical applications in biological systems.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Scheme 1
Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8
Fig. 9
Fig. 10
Fig. 11

Similar content being viewed by others

References

  1. Kramer R (1998) Fluorescent chemosensors for Cu2+ ions: fast, selective and highly sensitive. Angew Chem Int Ed 37:772–775

    Article  CAS  Google Scholar 

  2. Brummer O, Clair JL, Janda KD (1999) A colorimetric ligand for mercuric ion. Org Lett 1:415–419

    Article  Google Scholar 

  3. Choi MJ, Kim MY, Chang SK (2001) A new Hg2+-selective chromoionophore based on calix[4] arenediazacrown ether. Chem Commun 17:1664–1667

    Google Scholar 

  4. Woodroofe CC, Lippard SJ (2003) A novel two-fluorophore approach to ratiometric sensing of Zn2+. J Am Chem Soc 125:11458–11459

    Article  CAS  PubMed  Google Scholar 

  5. Lohar S, Banerjee A, Sahana A, Banik A, Mukhopadhyay SK, Das D (2013) A rhodamine–naphthalene conjugate as a FRET based sensor for Cr3+ and Fe3+ with cell staining application. Anal Methods 5:442–445

    Article  CAS  Google Scholar 

  6. Eastmond DA, Macgregor JT, Slesinski RS (2008) Trivalent chromium: assessing the genotoxic risk of an essential trace element and widely used human and animal nutritional supplement. Crit Rev Toxicol 38:173–190

    Article  CAS  PubMed  Google Scholar 

  7. Wang L, Wang L, Xia T, Dong L, Bian G, Chen H (2004) Direct fluorescence quantification of chromium(VI) in wastewater with organic nanoparticles sensor. Anal Sci 7:1013–1017

    Article  Google Scholar 

  8. Zhou Z, Yu M, Yang H, Huang K, Li F, Yi T, Huang C (2008) FRET-based sensor for imaging chromium(III) in living cells. Chem Commun 29:3387–3389

    Article  Google Scholar 

  9. Fu Q, Tang Y, Shi C, Zhang X, Xiang J, Liu X (2013) A novel fluorescence-quenching immune- chromatographic sensor for detection of the heavy metal chromium. Biosens Bioelectron 49:399–402

    Article  CAS  PubMed  Google Scholar 

  10. Li FM, Liu JM, Wang XX, Lin LP, Cai WL, Lin X, Zeng YN, Li ZM, Lin SQ (2011) Non-aggregation based label free colorimetric sensor for the detection of Cr(VI) based on selective etching of gold nanorods. Sensors Actuators B 155:817–822

    Article  CAS  Google Scholar 

  11. Gokel GW, Leevy WM, Weber ME (2004) Crown ethers: sensors for ions and molecular scaffolds for materials and biological models. Chem Rev 104:2723–2750

    Article  CAS  PubMed  Google Scholar 

  12. Zhang JF, Zhou Y, Yoon J, Kim JS (2011) Recent progress on fluorescent and colorimetric chemosensors for detection of precious metal ions (silver, gold and platinum ions). Chem Soc Rev 40:3416–3429

    Article  CAS  PubMed  Google Scholar 

  13. Duong TQ, Kim JS (2010) Fluoro- and chromogenic chemodosimeters for heavy metal ion detection in solution and biospecimens. Chem Rev 110:6280–6301

    Article  PubMed  Google Scholar 

  14. Formica M, Fusi V, Giorgi L, Micheloni M (2012) New fluorescent chemosensors for metal ions in solution. Coord Chem Rev 256:170–192

    Article  CAS  Google Scholar 

  15. Mao J, He Q, Liu WS (2010) An “off-on” fluorescence probe for chromium (III) ion determination in aqueous solution. Anal Bioanal Chem 396:1197–1203

    Article  CAS  PubMed  Google Scholar 

  16. Wan Y, Guo QJ, Wang XF, Xia AD (2010) Photophysical properties of rhodamine isomers: a two-photon excited fluorescent sensor for trivalent chromium cation (Cr3+). Anal Chim Acta 665:215–220

    Article  CAS  PubMed  Google Scholar 

  17. Wang DP, Shiraishi Y, Hirai T (2010) A distyryl BODIPY derivative as a fluorescent probe for selective detection of chromium (III). Tetrahedron Lett 51:2545–2549

    Article  CAS  Google Scholar 

  18. Zhou Y, Zhang J, Zhang L, Zhang Q, Ma T, Niu J (2013) A rhodamine–based fluorescent enhancement chemosensor for the detection of Cr3+ in aqueous media. Dyes Pigments 97:148–154

    Article  CAS  Google Scholar 

  19. Xie P, Guo F, Xiao Y, Jin Q, Yao D, Huang Z (2013) A fluorescent chemosensor based on rhodamine for Cr3+ in red spectral region in aqueous solutions and living cells. J Lumin 140:45–50

    Article  CAS  Google Scholar 

  20. Zhang D, Li M, Wang M, Wang J, Yang X, Ye Y, Zhao Y (2013) A rhodamine-phosphonate off–on fluorescent sensor for Hg2+ in natural water and its application in live cell imaging. Sensors Actuators B 177:997–1002

    Article  CAS  Google Scholar 

  21. Ma C, Zeng F, Wu G, Wu S (2012) A nanoparticle-supported fluorescence resonance energy transfer system formed via layer-by-layer approach as a ratiometric sensor for mercury ions in water. Anal Chim Acta 734:69–78

    Article  CAS  PubMed  Google Scholar 

  22. Job P (1928) Annalidi Chim 9:113–116

    CAS  Google Scholar 

  23. Standardization Administration of the People’s Republic of China, Standard examination methods for drinking water-metal parameters, GB/T 5750:6–2006

  24. Zhao Y, Sun Y, Lu X, Liu YL, Chen ML, Guo W (2010) Rhodamine-based chemosensor for Hg2+ in aqueous solution with a broad pH range and its application in live cell imaging. Org Biomol Chem 8:4143–4147

    Article  CAS  PubMed  Google Scholar 

  25. Gong YJ, Zhang XB, Chen Z, Yuan Y, Jin Z, Mei L, Zhang J, Tan WH, Shen GL, Yu RQ (2012) An efficient rhodamine thiospirolactam-based fluorescent probe for detection of Hg2+ in aqueous samples. Analyst 137:932–938

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgments

This work was financially supported by the National Science Foundation of China (nos. 20972143, 20972130) and Program for New Century Excellent Talents in University (NCET-11-0950).

Author information

Authors and Affiliations

  1. Phosphorus Chemical Engineering Research Center of Henan Province, the College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, China

    Man Li, Di Zhang, Yaqi Liu, Peigang Ding, Yong Ye & Yufen Zhao

  2. Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing, China

    Yong Ye & Yufen Zhao

Authors
  1. Man Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Di Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yaqi Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Peigang Ding
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Yong Ye
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Yufen Zhao
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Yong Ye.

Electronic supplementary material

Below is the link to the electronic supplementary material.

ESM 1

(DOCX 451 kb)

Rights and permissions

Reprints and permissions

About this article

Cite this article

Li, M., Zhang, D., Liu, Y. et al. A Novel Colorimetric and Off–On Fluorescent Chemosensor for Cr3+ in Aqueous Solution and its Application in Live Cell Imaging. J Fluoresc 24, 119–127 (2014). https://doi.org/10.1007/s10895-013-1275-x

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10895-013-1275-x

Keywords

Search

Navigation