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Determination of Paracetamol Based on its Quenching Effect on the Photoluminescence of CdTe Fluorescence Probes

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Abstract

L-Cysteine capped CdTe nanoparticles (NPs) were synthesized in aqueous medium, and their application as fluorescence probes in the determination of paracetamol was studied. The L-cysteine capped CdTe NPs were characterized by transmission electron microscopy, X-ray diffraction spectrometry, spectrofluorometry, ultraviolet-visible and Fourier transform infrared spectrometry. Based on the distinct fluorescence quenching of CdTe fluorescence probes in the presence of paracetamol, a simple, rapid and specific method for paracetamol determination was presented. Under optimum conditions, the relative fluorescence intensity of CdTe NPs was linearly proportional to paracetamol concentration from 1.0 × 10−8 mol/L to 1.6 × 10−7 mol/L with a detection limit of 4.2 × 10−9 mol/L. The proposed method was applied to detect paracetamol in commercial tablets with satisfactory results.

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Acknowledgements

This research is supported by the National Natural Science Foundation of China (No. 20975066, No. 41140031), the Nano-Foundation of Science and Techniques Commission of Shanghai Municipality (No. 0952nm01500), the Leading Academic Discipline Project of Shanghai Municipal Education Commission (No. J50102), and the Graduate Innovation Foundation of Shanghai University (SHUCX112027).

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Authors and Affiliations

  1. Department of Chemistry, Shanghai University, Shanghai, 200444, People’s Republic of China

    Li Li, Yaxiang Lu, Yaping Ding, Yu Cheng, Wanchen Xu & Fenfen Zhang

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  1. Li Li
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  2. Yaxiang Lu
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  3. Yaping Ding
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  4. Yu Cheng
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  5. Wanchen Xu
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  6. Fenfen Zhang
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Correspondence to Yaping Ding.

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Li, L., Lu, Y., Ding, Y. et al. Determination of Paracetamol Based on its Quenching Effect on the Photoluminescence of CdTe Fluorescence Probes. J Fluoresc 22, 591–596 (2012). https://doi.org/10.1007/s10895-011-0994-0

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  • DOI: https://doi.org/10.1007/s10895-011-0994-0

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