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Validated Spectroflurimetric Determination of Some H1 Receptor Antagonist Drugs in Pharmaceutical Preparations Through Charge Transfer Complexation

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Abstract

A validated simple, rapid, and selective spectrofluorimetric method was developed for the determination of some antihistaminic H1 receptor antagonist drugs namely ebastine (EBS), cetirizine dihydrochloride (CTZ), and fexofenadine hydrochloride (FXD). The method is based on the reaction of the cited drugs with some Π acceptors namely p-chloranilic acid (CLA), tetracyanoethylene (TCNE), and 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ) to give highly fluorescent derivatives. The fluorescence intensity—concentration plots were rectilinear over the concentration ranges of 0.2–3.0, 0.2–2.5 and 0.15–2.0 μg/ml for EBS with CLA, DDQ, and TCNE respectively; 0.5–7.0, 0.5–6.0, and 0.2–4.0 μg/ml for CTZ with the previously mentioned reagents, and 0.2–3.5, 0.5–6.0, and 0.2–3.5 μg/ml for FXD. The factors affecting the formation of the reaction products were carefully studied and optimized. The method was applied for the determination of the studied drugs in their dosage forms. The results obtained were in good agreement with those obtained by the comparison methods. Reactions Stoichiometries of the complexes formed between the studied drugs and Π acceptors were defined by the Job’s method of the continuous variation and found in 1:1 in all cases.

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Authors and Affiliations

  1. Department of Analytical Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt

    Mohie K. Sharaf El-Din, Fawzia Ibrahim, Manal I. Eid & Mary E. K. Wahba

Authors
  1. Mohie K. Sharaf El-Din
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  2. Fawzia Ibrahim
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  3. Manal I. Eid
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  4. Mary E. K. Wahba
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Correspondence to Mary E. K. Wahba.

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Sharaf El-Din, M.K., Ibrahim, F., Eid, M.I. et al. Validated Spectroflurimetric Determination of Some H1 Receptor Antagonist Drugs in Pharmaceutical Preparations Through Charge Transfer Complexation. J Fluoresc 22, 175–191 (2012). https://doi.org/10.1007/s10895-011-0944-x

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  • DOI: https://doi.org/10.1007/s10895-011-0944-x

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