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Metal-enhanced Singlet Oxygen Generation: A Consequence of Plasmon Enhanced Triplet Yields

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Abstract

In this Rapid Communication, we report the first observation of Metal-Enhanced singlet oxygen generation (ME1O2). Rose Bengal in close proximity to Silver Island Films (SiFs) can generate more singlet oxygen, a three-fold increase observed, as compared to an identical glass control sample but containing no silver. The enhanced absorption of the photo-sensitizer, due to coupling to silver surface plasmons, facilitates enhanced singlet oxygen generation. The singlet oxygen yield can potentially be adjusted by modifying the choice of MEF (Metal-Enhanced Fluorescence) & MEP (Metal Enhance Phosphorescence) parameters, such as distance dependence for plasmon coupling and wavelength emission of the coupling fluorophore. This is a most helpful observation in understanding the interactions between plasmons and lumophores, and this approach may well be of significance for singlet oxygen based clinical therapy.

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Fig. 1
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Fig. 3

Abbreviations

GR:

Green sensor

MEF:

Metal Enhanced Fluorescence

MEP:

Metal Enhanced Phosphorescence

ME1O2 :

Metal Enhanced Singlet Oxygen Generation

PDT:

Photodynamic Therapy

RB:

Rose Bengal

SiFs:

Silver Island Films

UV:

Ultraviolet

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Acknowledgement

The authors would like to thank UMBI for salary support. This work was also partially supported (partial salary support to CDG) by the NIH, NCRR RR008119.

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Authors and Affiliations

  1. Institute of Fluorescence, Laboratory for Advanced Medical Plasmonics, Medical Biotechnology Center, University of Maryland Biotechnology Institute, 725 West Lombard St, Baltimore, MD, 21201, USA

    Yongxia Zhang, Kadir Aslan, Michael J. R. Previte & Chris D. Geddes

  2. Center for Fluorescence Spectroscopy, Department of Biochemistry and Molecular Biology, Medical Biotechnology Center, University of Maryland School of Medicine, 725 West Lombard St, Baltimore, MD, 21201, USA

    Chris D. Geddes

Authors
  1. Yongxia Zhang
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  2. Kadir Aslan
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  3. Michael J. R. Previte
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  4. Chris D. Geddes
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Corresponding author

Correspondence to Chris D. Geddes.

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Zhang, Y., Aslan, K., Previte, M.J.R. et al. Metal-enhanced Singlet Oxygen Generation: A Consequence of Plasmon Enhanced Triplet Yields. J Fluoresc 17, 345–349 (2007). https://doi.org/10.1007/s10895-007-0196-y

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  • DOI: https://doi.org/10.1007/s10895-007-0196-y

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