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A Feasible and Quantitative Encoding Method for Microbeads with Multicolor Quantum Dots

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Abstract

Multicolor encoded beads were achieved by incorporating two color core-shell quantum dots (QDs) (CdSe/ZnS) to commercial polystyrene (PS) beads. By controlling the concentration ratios of the two quantum dots (QDs) in doping solutions, a series of codes with different intensity ratios were obtained. Based on the multiple encoded carboxylic modified polystyrene beads, fluorescent dyes labeled antibodies were distinguished successfully on the beads’ surface. It suggests that the encoded beads from this method have the practicability in biological applications and chemical analysis.

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Acknowledgements

The work was supported by the National High Technology Research and Development Program of China (863 Program: 2003AA234010), the National Natural Science Foundation of China (Grant No. 30670553, 30370387), the Trans-Century Training Program Foundation for Talents by the Ministry of Education, the Program for Distinguish Young Scientist of Hubei Province (2006ABB020).

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Authors and Affiliations

  1. Key Laboratory of Biomedical Photonics of Ministry of Education-Hubei Bioinformatics and Molecular Imaging Key Laboratory, Huazhong University of Science and Technology, Wuhan, HuBei, 430074, P.R. China

    Hai-Qiao Wang, Zhen-Li Huang, Tian-Cai Liu, Jian-Hao Wang, Yuan-Cheng Cao, Xiao-Feng Hua, Xiu-Qing Li & Yuan-Di Zhao

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  1. Hai-Qiao Wang
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  2. Zhen-Li Huang
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  3. Tian-Cai Liu
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  4. Jian-Hao Wang
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  5. Yuan-Cheng Cao
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  6. Xiao-Feng Hua
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  7. Xiu-Qing Li
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  8. Yuan-Di Zhao
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Corresponding author

Correspondence to Yuan-Di Zhao.

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Hai-Qiao Wang and Zhen-Li Huang authors contribute equally to this work

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Wang, HQ., Huang, ZL., Liu, TC. et al. A Feasible and Quantitative Encoding Method for Microbeads with Multicolor Quantum Dots. J Fluoresc 17, 133–138 (2007). https://doi.org/10.1007/s10895-007-0157-5

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  • DOI: https://doi.org/10.1007/s10895-007-0157-5

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