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RETRACTED ARTICLE: 3D Cu(II) Cluster-Based Coordination Polymer: Increasing the Activity of Prothrombin and Preventing Postpartum Hemorrhage

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This article was retracted on 24 January 2024

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Abstract

In the current study, via applying a hybrid-ligand method, a novel Cu(II)-based coordination polymer, formulated as [Cu2(OH)(bib)(bpt)]·H2O (1) (H3bpt = biphenyl-3,4′,5-tricarboxylic acid, bib = 1,4-bis(1-imidazolyl)benzene), has been successfully obtained by a isothermal method. Its treatment effect against postpartum hemorrhage was assessed in the bio-study. Firstly, through the model establishment and compound treatment, the prothrombin activity in the plasma was assessed by measuring the prothrombin time. Next, the levels of the factor XI and IX were also assessed by ELISA (enzyme linked immunosorbent assay detection kit). In addition to this, the prevention activity of the compound on the disseminated intravascular coagulation (DIC) during postpartum hemorrhage was also evaluated by measuring the inflammatory response of the inflammatory cytokines, such as IL-1β (interleukin-1β) and TNF-α (tumor necrosis factor-α). The inflammatory signaling relative expression was assessed via the real time RT-PCR (reverse transcription-polymerase chain reaction) as well. Above all, we can see that the compound has excellent treatment activity on DIC disease by inhibiting p53 and nf-κb relative expression in the endothelial cells.

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Acknowledgments

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Author notes

  1. Qin Pan and Yi Huang have contributed equally to this work.

Authors and Affiliations

  1. Obstetrics Department, Jingzhou Central Hospital, The Second Clinical Medical College of Yangtze University, Jingzhou, Hubei, China

    Qin Pan & Yi Huang

  2. Obstetrics Department, Gansu Provincial Maternity and Child Care Hospital, Lanzhou, Gansu, China

    Yan Dong

  3. Department of Medicine, Kunming Medical University, Kunming, Yunnan, China

    Gang-Gang Shi & Ya-Hong Wang

Authors
  1. Qin Pan
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  2. Yi Huang
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  3. Yan Dong
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  4. Gang-Gang Shi
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Correspondence to Yan Dong.

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This article has been retracted. Please see the retraction notice for more detail: https://doi.org/10.1007/s10876-024-02569-1

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Pan, Q., Huang, Y., Dong, Y. et al. RETRACTED ARTICLE: 3D Cu(II) Cluster-Based Coordination Polymer: Increasing the Activity of Prothrombin and Preventing Postpartum Hemorrhage. J Clust Sci 33, 1177–1183 (2022). https://doi.org/10.1007/s10876-021-02044-1

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  • DOI: https://doi.org/10.1007/s10876-021-02044-1

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