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Ultrasonication Mediated Fabrication of Glycine Coated Gadolinium Oxide Nanoparticles as MRI Contrast Agents

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Abstract

Gadolinium oxide nanoparticles (Gd2O3NPs) have recently gained significant interest because of their broad range of applications in biomedicine. Nevertheless, their functionality with amino acids was not clearly described. In the current study, the capability of sonication method in the Gd2O3NPs synthesis was explored for the first time. The process of sonication is a very effective technique for fabricating nanoparticles (NPs) which can uniformly disperse in liquids and hence this report describes the utilization of ultra-sonication method for the synthesis of uniform sized (25 nm) Gd2O3NPs coated with Glycine. Fourier transform- Infrared (FT-IR) spectroscopy and dynamic light scattering (DLS) studies were used for confirming the evaluation of Glycine conjugation with NPs. Plasma stability studies clearly showed that, as the time period of incubation increases, the hydrodynamic diameter of NPs in Glycine-Gd2O3 raises slightly to 40 ± 13 nm from 35.24 ± 1.6 nm in the initial stage. Furthermore, the relaxation time, T1 at various time points (1, 2, 4, 6, 9 and 24 h) during the incubation was determined and these values confirmed the excellent stability of Glycine-Gd2O3NPs MRI signal present in plasma.

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Authors and Affiliations

  1. Department of Ultrasound, The Affiliated Hangzhou First People’s Hospital of Zhejiang University School of Medicine, Hangzhou, 310003, China

    Chuanghua Chen, Jianhua Fang & Chenke Xu

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  1. Chuanghua Chen
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  2. Jianhua Fang
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Correspondence to Chenke Xu.

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Chen, C., Fang, J. & Xu, C. Ultrasonication Mediated Fabrication of Glycine Coated Gadolinium Oxide Nanoparticles as MRI Contrast Agents. J Clust Sci 32, 773–778 (2021). https://doi.org/10.1007/s10876-020-01836-1

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  • DOI: https://doi.org/10.1007/s10876-020-01836-1

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