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Auto-inflammation in a Patient with a Novel Homozygous OTULIN Mutation

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Fig. 1

References

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Acknowledgements

We kindly thank Saba Arshi, Mohammad Hassan Bemanian, Morteza Fallahpour, Alireza Nateghian, Farhad Abolhasan Chobdar, Davood Mansouri, Mehrnaz Mesdaghi, and Mojgan Kiani Amin for their cooperation and for their help in the work-up of the patient and taking care of the patient. We thank the patient and her family.

Research Funding

This work was supported by a Geconcerteerde Onderzoeksactie (GOA) grant from the Research Council of the Catholic University of Leuven, Belgium.

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Author notes

  1. Mohammad Nabavi, Mohammad Shahrooei, Hassan Rokni-Zadeh, Leen Moens and Xavier Bossuyt contributed equally to this work.

Authors and Affiliations

  1. Department of Allergy and Clinical Immunology, Iran University of Medical Sciences, Tehran, Iran

    Mohammad Nabavi & Kian Darabi

  2. Specialized Immunology Laboratory of Dr. Shahrooei, Ahvaz, Iran

    Mohammad Shahrooei

  3. Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium

    Mohammad Shahrooei, Isabelle Meyts, Leen Moens & Xavier Bossuyt

  4. Department of Medical Biotechnology, School of Medicine, Zanjan University of Medical Sciences (ZUMS), Zanjan, Iran

    Hassan Rokni-Zadeh

  5. Department of Chemistry Biochemistry, Molecular and Structural Biology Section, KU Leuven, Leuven, Belgium

    Jeroen Vrancken & Arnout Voet

  6. School of Mathematics, Institute for Research in Fundamental Sciences (IPM), Tehran, Iran

    Majid Changi-Ashtiani

  7. Department of Immunology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

    Mostafa Manian & Farhad Seif

  8. Neuroscience Research Center, Iran University of Medical Sciences, Tehran, Iran

    Farhad Seif

  9. Department of Pediatrics, University Hospitals Leuven, Herestraat 49, Leuven, Belgium

    Isabelle Meyts

  10. Department of Laboratory Medicine, University Hospitals Leuven, Herestraat 49, Leuven, Belgium

    Xavier Bossuyt

Authors
  1. Mohammad Nabavi
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  2. Mohammad Shahrooei
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  3. Hassan Rokni-Zadeh
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  4. Jeroen Vrancken
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  5. Majid Changi-Ashtiani
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  6. Kian Darabi
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  7. Mostafa Manian
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  8. Farhad Seif
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  9. Isabelle Meyts
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  10. Arnout Voet
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  11. Leen Moens
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  12. Xavier Bossuyt
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Contributions

Whole-exome sequencing, data analysis, and clinical diagnosis were done by Mohammad Shahrooei, Hassan Rokni-Zadeh, and Majid Changi-Ashtiani. Kian Darabi collected the data, Mostafa Manian gathered samples for analyses, and Farhad Seif made substantial contributions to design of the study and edited the draft. Mohammad Nabavi took care of the patient. Isabelle Meyts edited the draft. Jeroen Vrancken and Arnout Voet performed and described the modeling studies. Leen Moens and Xavier Bossuyt designed the experimental studies. Leen Moens performed the experimental analyses. Mohammad Nabavi and Xavier Bossuyt drafted the manuscript. All authors read and approved the manuscript.

Corresponding author

Correspondence to Xavier Bossuyt.

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The authors declare that they have no conflicts of interests.

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Nabavi, M., Shahrooei, M., Rokni-Zadeh, H. et al. Auto-inflammation in a Patient with a Novel Homozygous OTULIN Mutation. J Clin Immunol 39, 138–141 (2019). https://doi.org/10.1007/s10875-019-00599-3

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  • DOI: https://doi.org/10.1007/s10875-019-00599-3

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