References
Minegishi Y, Saito M, Tsuchiya S, Tsuge I, Takada H, Hara T, et al. Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome. Nature. 2007;448:1058–62.
Takashima T, Okamura M, Yeh TW, Okano T, Yamashita M, Tanaka K, et al. Multicolor flow cytometry for the diagnosis of primary immunodeficiency diseases. J Clin Immunol. 2017;37:486–95.
Milner JD, Brenchley JM, Laurence A, Freeman AF, Hill BJ, Elias KM, et al. Impaired T(H)17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome. Nature. 2008;452:773–6.
Czeizel AE, Rockenbauer M, Sorensen HT, Olsen J. The teratogenic risk of trimethoprim-sulfonamides: a population based case-control study. Reprod Toxicol. 2006;15:637–46.
Chandesris MO, Melki I, Natividad A, Puel A, Fieschi C, Yun L, et al. Autosomal dominant STAT3 deficiency and hyper-IgE syndrome: molecular, cellular, and clinical features from a French national survey. Medicine (Baltimore). 2012;91:e1–19.
Malek A, Sager R, Kuhn P, Nicolaides KH, Schneider H. Evolution of maternofetal transport of immunoglobulins during human pregnancy. Am J Reprod Immunol. 1996;36:248–55.
Freeman AF, Avila EM, Shaw PA, Davis J, Hsu AP, Welch P, et al. Coronary artery abnormalities in hyper-IgE syndrome. J Clin Immunol. 2011;31:338–45.
Acknowledgments
We thank the patients who participated in this study.
Funding
This work was partially supported by the Japan Ministry of Health, Labor, and Welfare (201711064A) and the AMED under Grant Number JP18ek0109218.
Author information
Authors and Affiliations
Contributions
ME wrote the manuscript and managed the pregnancies. KI and TM orchestrated the patients’ care. KI and YT reviewed the manuscript. All authors reviewed the manuscript and approved the final version.
Corresponding author
Ethics declarations
Conflict of Interest
The authors declare that they have no conflicts of interest.
Research Involving Human Participants
All procedures performed in the study were in accordance with the Helsinki principles.
Informed Consent
Written informed consent was obtained from both patients here presented.
Additional information
Publisher’s Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Electronic Supplementary Material
Supplemental Figure 1
Changes in serum IgG and IgE concentrations in the two neonates. (PPTX 63 kb)
Rights and permissions
About this article
Cite this article
Egawa, M., Imai, K., Taketani, Y. et al. Two Prenatal Cases of Hyper-IgE Syndrome. J Clin Immunol 39, 15–18 (2019). https://doi.org/10.1007/s10875-018-0588-6
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10875-018-0588-6