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Helicobacter bilis-Associated Suppurative Cholangitis in a Patient with X-Linked Agammaglobulinemia

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Abstract

ᅟ

Helicobacter bilis is a commensal bacterium causing chronic hepatitis and colitis in mice. In humans, enterohepatic Helicobacter spp. are associated with chronic hepatobiliary diseases.

Purpose

We aimed at understanding the microbial etiology in a patient with X-linked agammaglobulinemia presenting with suppurative cholangitis.

Methods

16S rDNA PCR directly performed on a liver biopsy retrieved DNA of H. bilis.

Results

Clinical outcome resulted in the normalization of clinical and biological parameters under antibiotic treatment by a combination of ceftriaxone, metronidazole, and doxycyclin followed by a 2-week treatment with moxifloxacin and a 2-month treatment with azithromycin.

Conclusion

In conclusion, these data suggest a specific clinical and microbiological approach in patients with humoral deficiency in order to detect H. bilis hepatobiliary diseases.

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References

  1. Rosey AL, Abachin E, Quesnes G, et al. Development of a broad-range 16S rDNA real-time PCR for the diagnosis of septic arthritis in children. J Microbiol Methods. 2007;68:88–93.

    Article  CAS  PubMed  Google Scholar 

  2. Labigne A, Cussac V, Courcoux P. Development of genetic and molecular approaches for the diagnosis and study of the pathogenicity of Helicobacter pylori, agent of gastric inflammatory diseases. Bull Acad Natl Med. 1991;175(6):791–800.

    CAS  PubMed  Google Scholar 

  3. Fox JG, Yan LL, Dewhirst FE, et al. Helicobacter bilis sp. nov., a novel Helicobacter species isolated from bile, livers, and intestines of aged, inbred mice. J Clin Microbiol. 1995;33(2):445–54.

    CAS  PubMed  PubMed Central  Google Scholar 

  4. Hänninen ML, Kärenlampi RI, Koort JMK, et al. Extension of the species Helicobacter bilis to include the reference strains of Helicobacter sp. Flexispira taxa 2, 3 and 8 and Finnish canine and feline Flexispira strains. Int J Syst Evol Microbiol. 2005;55(Pt 2):891–8.

    Article  PubMed  Google Scholar 

  5. Eaton KA, Dewhirst FE, Paster BJ, et al. Prevalence and varieties of Helicobacter species in dogs from random sources and pet dogs: animal and public health implications. J Clin Microbiol. 1996;34(12):3165–70.

    CAS  PubMed  PubMed Central  Google Scholar 

  6. Segura-Lopez FK, Guitron-Cantu A, Torres J. Association between Helicobacter spp. infections and hepatobiliary malignancies: a review. World J Gastroenterol. 2015;21(5):1414–23.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Takayama S, Takahashi H, Matsuo Y, et al. Effect of Helicobacter bilis infection on human bile duct cancer cells. Dig Dis Sci. 2010;55(7):1905–10.

    Article  PubMed  Google Scholar 

  8. Kerton A, Warden P. Review of successful treatment for Helicobacter species in laboratory mice. Lab Anim. 2006;40(2):115–22.

    Article  CAS  PubMed  Google Scholar 

  9. Turvey SE, Leo SH, Boos A, et al. Successful approach to treatment of Helicobacter bilis infection in X-linked agammaglobulinemia. J Clin Immunol. 2012;32:1404–8.

    Article  PubMed  Google Scholar 

  10. Franklin CL, Riley LK, Livingston RS, et al. Enterohepatic lesions in SCID mice infected with Helicobacter bilis. Lab Anim Sci. 1998;48:334–9.

    CAS  PubMed  Google Scholar 

  11. Simons E, Spacek LA, Lederman HM, et al. Helicobacter cinaedi bacteremia presenting as macules in an afebrile patient with X-linked agammaglobulinemia. Infection. 2004;32(6):367–8.

    Article  CAS  PubMed  Google Scholar 

  12. Han S, Schindel C, Genitsariotis R, Marker-Hermann E, et al. Identification of a unique Helicobacter species by 16S rRNA gene analysis in an abdominal abscess from a patient with X-linked hypogammaglobulinemia. J Clin Microbiol. 2000;38(7):2740–2.

    CAS  PubMed  PubMed Central  Google Scholar 

  13. Murray PR, Jain A, Uzel G, Ranken R, Ivy C, Blyn LB, et al. Pyoderma gangrenosum-like ulcer in a patient with X-linked agammaglobulinemia: identification of Helicobacter bilis by mass spectrometry analysis. Arch Dermatol. 2010;146(5):523–6.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Segura-Lopez FK, Aviles-Jimenez F, Guitron-Cantu A, et al. Infection with Helicobacter bilis but not Helicobacter hepaticus was associated with extrahepatic cholangiocarcinoma. Helicobacter. 2015;20(3):223–30.

    Article  CAS  PubMed  Google Scholar 

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Acknowledgements

We thank Agnès Labigne, Unité de Pathogénie bactérienne des muqueuses, Institut Pasteur, Paris, France, for her help in this case report.

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Author notes

  1. Nicolas Degand

    Present address: CHU de Nice, Laboratoire de Bactériologie, 151 route St Antoine de Ginestière, BP 3079, 06202, Nice, Cedex 3, France

  2. Justine Dautremer, Benoît Pilmis, Olivier Lortholary, and Marc Lecuit contributed equally to this work.

Authors and Affiliations

  1. Université Paris Descartes - Sorbonne Paris Cité, Laboratoire de Microbiologie, Hôpital Necker-Enfants Malades, Assistance Publique - Hôpitaux de Paris, Paris, France

    Nicolas Degand, Agnès Ferroni & Xavier Nassif

  2. Université Paris Descartes - Sorbonne Paris Cité, Service de Maladies infectieuses et Tropicales, Hôpital Necker-Enfants Malades, Centre d’Infectiologie Necker-Pasteur, Assistance Publique - Hôpitaux de Paris, Paris, France

    Justine Dautremer, Fanny Lanternier, Olivier Lortholary & Marc Lecuit

  3. Université Paris Descartes - Sorbonne Paris Cité, Service d’Anatomopathologie, Hôpital Necker-Enfants Malades, Assistance Publique - Hôpitaux de Paris, Paris, France

    Benoît Pilmis & Julie Bruneau

  4. Université Paris Descartes - Sorbonne Paris Cité, Service d’Hématologie, Hôpital Necker-Enfants Malades, Assistance Publique - Hôpitaux de Paris, Paris, France

    Olivier Hermine

  5. Université Paris Descartes - Sorbonne Paris Cité, Service d’Immuno-hématologie pédiatrique, Hôpital Necker-Enfants Malades, Assistance Publique - Hôpitaux de Paris, Paris, France

    Stéphane Blanche

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  1. Nicolas Degand
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  2. Justine Dautremer
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  3. Benoît Pilmis
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  8. Stéphane Blanche
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  9. Xavier Nassif
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  11. Marc Lecuit
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Corresponding author

Correspondence to Nicolas Degand.

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The authors declare that they have no conflict of interest.

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Degand, N., Dautremer, J., Pilmis, B. et al. Helicobacter bilis-Associated Suppurative Cholangitis in a Patient with X-Linked Agammaglobulinemia. J Clin Immunol 37, 727–731 (2017). https://doi.org/10.1007/s10875-017-0437-z

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  • DOI: https://doi.org/10.1007/s10875-017-0437-z

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