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Persistent Impairment of T-Cell Regeneration in a Patient with Activated PI3K δ Syndrome

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References

  1. Angulo I, Vadas O, Garcon F, Banham-Hall E, Plagnol V, et al. Phosphoinositide 3-kinase delta gene mutation predisposes to respiratory infection and airway damage. Science. 2013;342(6160):866–71.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Lucas CL, Kuehn HS, Zhao F, Niemela JE, Deenick EK, et al. Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110delta result in T cell senescence and human immunodeficiency. Nat Immunol. 2014;15(1):88–97.

    Article  CAS  PubMed  Google Scholar 

  3. Rae W, Ramakrishnan KA, Gao Y, Ashton-Key M, Pengelly RJ, et al. Precision treatment with sirolimus in a case of activated phosphoinositide 3-kinase delta syndrome. Clin Immunol. 2016;171:38–40.

    Article  CAS  PubMed  Google Scholar 

  4. Chapman NM, Chi HB. mTOR links environmental signals to T cell fate decisions. Front Immunol. 2015;5:1–11.

    Article  Google Scholar 

  5. Kerdiles YM, Beisner DR, Tinoco R, Dejean AS, Castrillon DH, et al. Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor. Nat Immunol. 2009;10(2):176–84.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Acknowledgements

The manuscript was proofread and edited by Dr. Julian Tang of the Department of Education for Clinical Research, National Center for Child Health and Development (NCCHD). We would like to thank the patient and family for their cooperation. We are also grateful to Nobuyuki Watanabe and other laboratory staff at the Department of Human Genetics, NCCHD for their excellent support. This work was supported by grants from the Japan Agency for Medical Research and Development, Japan (Grant number: 15gk0110005h0103), and the NCCHD (Grant number: 25-1) (Masafumi Onodera).

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Correspondence to Toru Uchiyama.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amenders or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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The authors declare that they have no conflict of interest.

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Goto, F., Uchiyama, T., Nakazawa, Y. et al. Persistent Impairment of T-Cell Regeneration in a Patient with Activated PI3K δ Syndrome. J Clin Immunol 37, 347–350 (2017). https://doi.org/10.1007/s10875-017-0393-7

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  • DOI: https://doi.org/10.1007/s10875-017-0393-7

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