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Neurologic Complications of Common Variable Immunodeficiency

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Abstract

Common variable immunodeficiency is a rare disorder of immunity associated with a myriad of clinical manifestations including recurrent infections, autoimmunity, and malignancy. Though rare, neurologic complications have been described in a small number of case reports and case series of CVID patients. In this article, we present a patient with CVID who suffered significant neurologic morbidity and categorize the reported range of neurologic complications associated with CVID. Our case highlights the complex nature of neurologic manifestations in CVID patients, and our review of the current database suggests that infection and inflammatory neurologic disorders are the cause of most neurologic presentations.

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Authors and Affiliations

  1. Division of Allergy and Immunology, University of California, San Francisco, 400 Parnassus Ave, San Francisco, CA, 94143, USA

    Jenna Thuc-Uyen Nguyen & Katherine Gundling

  2. Department of Neurology, University of California, San Francisco, CA, USA

    Ari Green & Michael R. Wilson

  3. Department of Ophthalmology, University of California, San Francisco, CA, USA

    Ari Green

  4. Department of Biochemistry and Biophysics, University of California, San Francisco, CA, USA

    Joseph L. DeRisi

  5. Howard Hughes Medical Institute, Chevy Chase, MD, USA

    Joseph L. DeRisi

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  1. Jenna Thuc-Uyen Nguyen
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Correspondence to Jenna Thuc-Uyen Nguyen.

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Nguyen, J.TU., Green, A., Wilson, M.R. et al. Neurologic Complications of Common Variable Immunodeficiency. J Clin Immunol 36, 793–800 (2016). https://doi.org/10.1007/s10875-016-0336-8

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