Abstract
CD8A encodes the CD8α chain of the dimeric CD8 protein, a critical coreceptor of cytotoxic T cells. We report here the comprehensive immunological evaluation of a child with a CD8A missense mutation, providing evidence that CD8 deficiency increases susceptibility to recurrent respiratory infections without interfering with the TCR-mediated proliferation of T cells. These observations expand the known phenotypes associated with CD8 deficiency.
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Acknowledgments
We would like to thank the patient and his relatives. We also thank Stéphanie Ndaga, Aminata Diabate, Marie Duchamp, Nathalie Lambert and Virginie Grandin for technical assistance. We would like to thank Drs Estela Paz-Artal and Esther Mancebo Sierra for advice about genetic techniques.
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Despina Moshous and Capucine Picard contributed equally.
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Dumontet, E., Osman, J., Guillemont-Lambert, N. et al. Recurrent Respiratory Infections Revealing CD8α Deficiency. J Clin Immunol 35, 692–695 (2015). https://doi.org/10.1007/s10875-015-0213-x
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DOI: https://doi.org/10.1007/s10875-015-0213-x