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Matrix Metalloproteinases: A Review of Their Structure and Role in Systemic Sclerosis

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Abstract

Matrix metalloproteinases (MMPs) are the main enzymes involved in arterial wall extracellular matrix (ECM) degradation and remodeling, whose activity has been involved in various normal and pathologic processes, such as inflammation, fibrosis. As a result, the MMPs have come to consider as both therapeutic targets and diagnostic tools for the treatment and diagnosis of autoimmune diseases, including systemic lupus erythematosus and rheumatoid arthritis. Systemic sclerosis (SSc) is a rare autoimmune disease of unknown etiology characterized by an excessive over-production of collagen and other ECM, resulting in skin thickening and fibrosis of internal organs. In recent years, abnormal expression of MMPs has been demonstrated with the pathogenesis of SSc, and the association of different polymorphisms on MMPs genes with SSc has been extensively studied. This review describes the structure, function and regulation of MMPs and shortly summarizes current understanding on experimental findings, genetic associations of MMPs in SSc.

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Acknowledgments

This work was partly supported by grants from the Academic Leader Foundation of Anhui Medical University and the Key Project of the Education Department of Anhui Province Natural Science Research (Code: KJ2012A165).

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Authors and Affiliations

  1. Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, People’s Republic of China

    Wen-jia Peng, Jun-wei Yan, Ya-nan Wan, Bing-xiang Wang, Hai-feng Pan & Jing Wang

  2. Department of Rheumatology, Anhui Provincial Hospital, Hefei, China

    Jin-hui Tao & Guo-jun Yang

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  1. Wen-jia Peng
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  2. Jun-wei Yan
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  3. Ya-nan Wan
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  4. Bing-xiang Wang
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  5. Jin-hui Tao
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  6. Guo-jun Yang
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  7. Hai-feng Pan
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Correspondence to Jing Wang.

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Wen-jia Peng and Jun-wei Yan contributed equally to this work

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Peng, Wj., Yan, Jw., Wan, Yn. et al. Matrix Metalloproteinases: A Review of Their Structure and Role in Systemic Sclerosis. J Clin Immunol 32, 1409–1414 (2012). https://doi.org/10.1007/s10875-012-9735-7

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  • DOI: https://doi.org/10.1007/s10875-012-9735-7

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