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Polymorphisms in the CTLA-4 Gene and Rheumatoid Arthritis Susceptibility: A Meta-analysis

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Abstract

Introduction

The +49A/G polymorphism and CT60 polymorphism in the CTLA-4 gene have been extensively examined for the association with rheumatoid arthritis (RA); however, results of different studies have been inconclusive. The aim of this study is to comprehensively evaluate the genetic risks of +49A/G and CT60 polymorphisms in the CTLA-4 gene for RA.

Methods

A meta-analysis was carried out to analyze the association of +49A/G and CT60 polymorphisms with RA risk.

Results

A total of 30 case–control studies in 20 articles were included in this meta-analysis. The results indicated that the variant G allele carriers (GG + GA) of +49A/G polymorphism had an 18% increased risk of RA when compared with the homozygote AA (odds ratio (OR) = 1.18, 95% confidence interval (CI): 1.04–1.34 for GG + AG vs. AA). In addition, the variant CT60 A allele carriers of CT60 polymorphism had a 14% decreased risk of RA when compared with the homozygote GG (OR = 0.86, 95%CI = 0.78–0.95 for AA + AG vs. GG). In the subgroup analysis by ethnicity, significant elevated RA risks were associated with +49G allele carriers in Asians, but not in Europeans. However, for CT60 polymorphism, significant decreased RA risks were associated with CT60 A allele carriers in Europeans, but not in Asians.

Conclusions

This meta-analysis suggested that the +49A/G and CT60 polymorphisms in the CTLA-4 gene may be risk factors for RA.

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Acknowledgments

This study was supported by grant #2011Sz0140 from the Key Projects in the National Science of Sichuan province.

Conflict of Interest Disclosure

None declared.

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Authors and Affiliations

  1. The 452nd Military Hospital of China, Chengdu, Sichuan, 610041, China

    Xiaobo Li, Cong Zhang, Zhanzhong Qi, Xin Zhang & Xingqiong Xiao

  2. West China Medical School, Sichuan University, Chengdu, Sichuan, 610041, China

    Yonggang Zhang & Zhangpeng Xiang

  3. Key Laboratory of Laboratory Medicine, Ministry of Education, Zhejiang Provincial Key Laboratory of Medical Genetics, Wenzhou Medical College, Wenzhou, Zhejiang, 325035, China

    Jie Zhang

  4. Department of Laboratory Medicine, The 10th Hospital of Chengdu, Chengdu, Sichuan, 610041, China

    Zhangjun Wu

  5. Department of Laboratory Medicine, Chengdu Women and Children’s Medical Center, Chengdu, Sichuan, 610041, China

    Lian Yang

  6. The 452nd Military Hospital of China, Gongnongyuan Jie 1#, Chengdu, Sichuan, 610041, China

    Xiaobo Li

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  1. Xiaobo Li
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Correspondence to Xiaobo Li.

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Li, X., Zhang, C., Zhang, J. et al. Polymorphisms in the CTLA-4 Gene and Rheumatoid Arthritis Susceptibility: A Meta-analysis. J Clin Immunol 32, 530–539 (2012). https://doi.org/10.1007/s10875-012-9650-y

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  • DOI: https://doi.org/10.1007/s10875-012-9650-y

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