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Aging Affects Human B Cell Responses

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Abstract

Aging represents a complex remodeling in which both innate and adaptive immunities deteriorate. Age-related changes in humoral immunity are responsible for the reduced vaccine responses observed in elderly individuals. Although T cell alterations play a significant role in age-related humoral immune changes, alterations in B cells also occur. We here provide an overview of age-related changes in B cell markers and functions. Our studies have shown that intrinsic changes in B cells with age contribute to reduced antibody responses such as those to the influenza vaccine.

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Acknowledgements

This work is supported by NIH AG-17618 and AG-28586 (BBB).

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  1. Department of Microbiology and Immunology, University of Miami Miller School of Medicine, RMSB 3146A, P.O. Box 016960(R-138), Miami, FL, 33101, USA

    Daniela Frasca & Bonnie B. Blomberg

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  1. Daniela Frasca
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Correspondence to Daniela Frasca.

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Frasca, D., Blomberg, B.B. Aging Affects Human B Cell Responses. J Clin Immunol 31, 430–435 (2011). https://doi.org/10.1007/s10875-010-9501-7

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