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Adoptive-Transfer Effects of Intravenous Immunoglobulin in Autoimmunity

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Abstract

Intravenous immunoglobulin (IVIG) is an effective treatment for a variety of autoimmune and inflammatory conditions. The mechanism of action of IVIG remains poorly understood, but a variety of theories have been suggested. Recent studies in murine models have indicated that some of the ameliorative effects of IVIG in autoimmunity can be repeated by the adoptive transfer of leukocytes that have been primed with IVIG. The active cell component within the leukocyte cell population in immune thrombocytopenia (ITP) was determined to be CD11c+ dendritic cells. This review will highlight recent work in murine systems that indicates that the effects of IVIG can be adoptively transferred in some autoimmune diseases and inflammatory states.

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Acknowledgments

I thank Andrew R. Crow for his critical review of this manuscript.

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Authors and Affiliations

  1. The Canadian Blood Services, Alta Vista Drive, Ottawa, ON, 1800, Canada

    Alan H. Lazarus

  2. The Keenan Research Centre in the Li Ka Shing Knowledge Institute, St. Michael’s Hospital, 30 Bond St., Toronto, ON, Canada, M5B 1W8

    Alan H. Lazarus

  3. The Toronto Platelet Immunobiology Group, Toronto, ON, Canada

    Alan H. Lazarus

  4. Departments of Medicine, Laboratory Medicine and Pathobiology of the University of Toronto, Toronto, ON, Canada

    Alan H. Lazarus

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  1. Alan H. Lazarus
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Correspondence to Alan H. Lazarus.

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Lazarus, A.H. Adoptive-Transfer Effects of Intravenous Immunoglobulin in Autoimmunity. J Clin Immunol 30 (Suppl 1), 20–23 (2010). https://doi.org/10.1007/s10875-010-9410-9

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  • DOI: https://doi.org/10.1007/s10875-010-9410-9

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