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Role of Endogenous and Induced Regulatory T Cells During Infections

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Abstract

Background

Various populations of regulatory cells, including Foxp3+ TReg, have been shown to play a central role in the maintenance of peripheral homeostasis and establishment of controlled immune responses.

Objective

In this review, we discuss current hypotheses and points of polemic associated with the origin, mode of action, and antigen specificity of both endogenous and induced regulatory T cells during infections.

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Acknowledgements

This work was supported by the Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health. We would like to thank David B. Chow for the confocal image. We apologize to those authors whose work we were unable to cite because of space limitations.

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  1. Mucosal Immunology Unit, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 4 Center Drive, Room 4/126, Bethesda, MD, 20892, USA

    Elizabeth Wohlfert & Yasmine Belkaid

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  1. Elizabeth Wohlfert
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Correspondence to Yasmine Belkaid.

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Wohlfert, E., Belkaid, Y. Role of Endogenous and Induced Regulatory T Cells During Infections. J Clin Immunol 28, 707–715 (2008). https://doi.org/10.1007/s10875-008-9248-6

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