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Lack of Association of the Vascular Endothelial Growth Factor Gene Polymorphisms with Kawasaki Disease in Taiwanese Children

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Abstract

Introduction

Kawasaki disease (KD) is an acute febrile vasculitis of unknown etiology that mainly occurs in infants and children. Clinical and histopathologic findings suggest that vascular endothelial growth factor (VEGF) is involved in the coronary artery lesions (CALs) development in KD. This study hypothesized that specific VEGF gene polymorphisms and their haplotypes are associated with KD susceptibility and CAL development in Taiwanese children.

Subjects and Methods

The VEGF −2578 A/C, −634 G/C, and +936 C/T single-nucleotide polymorphisms (SNPs) were genotyped in 156 children with KD and 672 ethnically matched healthy controls using the Pre-Developed TaqMan Allelic Discrimination Assay.

Results

No significant differences in genotype, allele, carrier, and haplotype frequencies of the three SNPs were found between healthy controls and children with KD or between patients with and without CAL.

Conclusion

Our data suggest that VEGF −2578 A/C, −634 G/C, and +936 C/T SNPs do not confer increased susceptibility to KD or to CAL development.

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Acknowledgements

This research was supported by grants NSC 94-2314-B-195-012 from National Science Council, Executive Yuan and MMH 9480 and MMH E-95007 from Mackay Memorial Hospital, Taiwan. We thank Dr. Mary Jeanne Buttrey for her review and criticism of this paper.

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Authors and Affiliations

  1. Department of Pediatrics, Mackay Memorial Hospital, 45, Min-Sheng Rd., Tamshui, 25115, Taipei, Taiwan

    Fu-Yuan Huang, Ming-Ren Chen, Hung-Chang Lee, Hsin Chi, Nan-Chang Chiu, Chyong-Hsin Hsu, Shuan-Pei Lin, Hsin-An Kao & Yann-Jinn Lee

  2. Department of Medical Research, Mackay Memorial Hospital, Tamshui, 25115, Taipei, Taiwan

    Tzu-Yang Chang, Shuan-Pei Lin, Wei-Fang Chen, Hui-Wen Chan, Hsin-Fu Liu, Chen-Chung Chu, Marie Lin & Yann-Jinn Lee

  3. Department of Pediatrics, Taipei Medical University, Taipei, Taiwan

    Fu-Yuan Huang, Hung-Chang Lee, Hsin-An Kao & Yann-Jinn Lee

  4. Mackay Medicine, Nursing and Management College, Taipei, Taiwan

    Ming-Ren Chen, Hsin Chi, Nan-Chang Chiu & Shuan-Pei Lin

  5. Department of Infant and Child Care, National Taipei College of Nursing, Taipei, Taiwan

    Shuan-Pei Lin

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  1. Fu-Yuan Huang
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Correspondence to Yann-Jinn Lee.

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Huang, FY., Chang, TY., Chen, MR. et al. Lack of Association of the Vascular Endothelial Growth Factor Gene Polymorphisms with Kawasaki Disease in Taiwanese Children. J Clin Immunol 28, 322–328 (2008). https://doi.org/10.1007/s10875-008-9185-4

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  • DOI: https://doi.org/10.1007/s10875-008-9185-4

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