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Polymorphisms of Genes for Programmed Cell Death 1 Ligands in Patients with Rheumatoid Arthritis

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Abstract

To investigate the role of ligands for programmed cell death 1 (PD-L) in the pathogenesis of rheumatoid arthritis (RA), 129 patients with RA and 125 unrelated healthy controls were enrolled in this study. The PD-L1 and PD-L2 polymorphisms were determined by the method of polymerase chain reaction (PCR)/direct sequencing or PCR/reaction fragment length polymorphisms. The genotype distributions of PD-L1 6777 C/G were not significantly different between the patients with RA and healthy controls. There was also no significant difference in the allele frequencies of PD-L1 6777 C/G polymorphisms between the patients with RA and controls. Similar findings could also be found in the phenotypes and alleles frequencies of PD-L2 47103 C/T and 47139 T/C polymorphisms between the patients with RA and controls. The patients with PD-L1 6777 G had higher prevalence of rheumatoid nodule in comparison with those without PD-L1 6777 G (p = 0.005, OR = 4.0, 95% CI = 1.5–10.9). In contrast, the PD-L2 47103 C/T and 47139 T/C polymorphisms were not related to the occurrence of rheumatoid nodule. This study demonstrated that the PD-L1 and PD-L2 polymorphisms were not associated with susceptibility to RA in Taiwan. PD-L1 6777 G was associated with the prevalence of rheumatoid nodule.

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Authors and Affiliations

  1. Department of Laboratory Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan

    Shu-Chen Wang

  2. Division of Rheumatology, Department of Internal Medicine, Kaohsiung Medical University Hospital, 100 Zihyou 1st Road, Kaohsiung City, 807, Taiwan

    Chia-Hui Lin, Tsan-Teng Ou, Cheng-Chin Wu, Wen-Chan Tsai, Hong-Wen Liu & Jeng-Hsien Yen

  3. Faculty of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Kaohsiung, Taiwan

    Ruei-Nian Li

  4. Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan

    Jeng-Hsien Yen

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  1. Shu-Chen Wang
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Correspondence to Jeng-Hsien Yen.

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Shu-Chen Wang and Chia-Hui Lin contributed equally to this work.

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Wang, SC., Lin, CH., Li, RN. et al. Polymorphisms of Genes for Programmed Cell Death 1 Ligands in Patients with Rheumatoid Arthritis. J Clin Immunol 27, 563–567 (2007). https://doi.org/10.1007/s10875-007-9113-z

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  • DOI: https://doi.org/10.1007/s10875-007-9113-z

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