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Variations in Plasmacytoid Dendritic Cell (PDC) and Myeloid Dendritic Cell (MDC) Levels in HIV-Infected Subjects on and off Antiretroviral Therapy

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Abstract

Plasmacytoid and myeloid dendritic cells are reduced in AIDS patients. The number of these circulating cells was assessed cross-sectionally and longitudinally in 27 uninfected and 72 HIV-infected subjects on and off antiretroviral therapy. The plasmacytoid dendritic cell numbers were significantly reduced in the HIV-infected subjects compared to controls (p < 0.001). This reduction correlated directly with CD4+ cell counts (p < 0.001) and inversely with viral load (p < 0.001). These associations were found to a lesser degree for the myeloid dendritic cells. Intra-assay variability of these dendritic cell counts was < 10%. Antiretroviral therapy significantly increased plasmacytoid dendritic cell (p < 0.001) and CD4+ cell (p = 0.05) counts at 8 months by 76.9% and 19%, respectively. The plasmacytoid dendritic cell levels responded more readily to viral load increases and decreases than CD4+ cells. Circulating plasmacytoid dendritic cells may provide important additional information about immune function in HIV-infected subjects receiving or not receiving antiretroviral therapy.

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Authors and Affiliations

  1. Division Hematology/Oncology, Department of Medicine, University of California, San Francisco, California

    Barbara Schmidt, Sue H. Fujimura & Jay A. Levy

  2. Department of Epidemiology and Biostatistics, University of California, San Francisco, California

    Jeffrey N. Martin

  3. Division of Hematology/Oncology, Department of Medicine, University of California School of Medicine, San Francisco, California, 94143-1270

    Jay A. Levy

Authors
  1. Barbara Schmidt
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  2. Sue H. Fujimura
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  3. Jeffrey N. Martin
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  4. Jay A. Levy
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Correspondence to Jay A. Levy.

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Schmidt, B., Fujimura, S.H., Martin, J.N. et al. Variations in Plasmacytoid Dendritic Cell (PDC) and Myeloid Dendritic Cell (MDC) Levels in HIV-Infected Subjects on and off Antiretroviral Therapy. J Clin Immunol 26, 55–64 (2006). https://doi.org/10.1007/s10875-006-8401-3

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  • DOI: https://doi.org/10.1007/s10875-006-8401-3

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