Despite relatively standardized surgical procedures, patients undergoing total knee replacement (TKR) surgery differ dramatically in the speed of their recovery. Previous research has suggested a relationship between the experience of pain and sleep disruptions among patients with chronic pain or those undergoing surgery, such that more severe pain is associated with more frequent awakenings throughout the night. This study examined sleep disruptions 1 month following surgery as a mediator of the relationship between pain 1 month following surgery and functional limitations 3 months following surgery. A total of 110 patients scheduled to undergo unilateral TKR were examined at three time points: 2–3 weeks prior to surgery, 1 month following surgery, and 3 months following surgery. After controlling for presurgical levels of pain, sleep disruptions, and functional limitations, sleep disruptions 1 month following surgery partially mediated the relationship between pain 1 month following surgery and functional limitations 3 months following surgery. The present findings underscore the importance of adequate sleep during postsurgical recovery and suggest that interventions targeting sleep disruptions may improve the speed and quality of patients’ recovery from TKR and other surgical procedures.
Similar content being viewed by others
REFERENCES
Agargun, M. Y., Tekeoglu, I., Gunes, A., et al. (1999). Sleep quality and pain threshold in patients with fibromyalgia. Comp. Psychiatry 40: 226–228.
Atkinson, J. H., Ancoli-Israel, S., Slater, M. A., et al. (1988). Subjective sleep disturbance in chronic back pain. Clin. J. Pain 4: 225–232.
Baron, R. M., and Kenny, D. A. (1986). The moderator–mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations. J. Pers. Soc. Psychol. 51: 1173–1182.
Bellamy, N., Buchanan, W. W., Goldsmith, C. H., Campbell, J., and Stitt, L. (1988). Validation study of the WOMAC: A health status instrument for measuring clinically important patient relevant outcomes following total hip or knee arthroplasty in osteoarthritis. J. Orthop. Rheum. 1: 95–108.
Boeke, S., Stronks, D., Verhahe, F., and Zwavelig, A. (1991). Psychological variables as predictors of the length of post-operative hospitalization. J. Psychosom. Res. 35: 281– 288.
Brimacombe, J., and Macfie, A. G. (1993). Peri-operative nightmares in surgical patients. Anaesthesia 48: 527–529.
Buysse, D. J., Reynolds, C. F., Monk, T. H., Berman, S. R., and Kupfer, D. J. (1989). The Pittsburgh Sleep Quality Index: A new instrument for psychiatric practice and research. Psychiatry Rev. 28: 193–213.
Christensen, T., and Kehlet, H. (1984). Post-operative fatigue and changes in nutritional status. Br. J. Surg. 71: 473–476.
Cronin, A. J., Keifer, J. C., Davies, M. F., et al. (2001). Post-operative sleep disturbance: Influences of opioids and pain in humans. Sleep 24(1): 39–44.
Croog, S. H., Baume, R. M., and Nalbandian, J. (1995). Pre-surgery psychological characteristics, pain response, and activities impairment in female patients with repeated periodontal surgery. J. Psychosom. Res., 39: 39–51.
DeCherney, A. H., Bachmann, G., Isaacson, K., and Gall, S. (2002). Post-operative fatigue negatively impacts the daily lives of patients recovering from hysterectomy. Obstet. Gynecol. 99: 51–57.
Edwards, H., Rose, E. A., and King, T. C. (1982). Post-operative deterioration in muscular function. Arch. Surg. 117: 899– 901.
Faul, F., and Erdfelder, E. (1992). GPOWER: A priori, post-hoc, and compromise power analysis for MS-DOS [Computer program], Department of Psychology, Bonn University, Bonn, Germany.
Gradisar, I., Greene, K., Kepley, R., and Bear. T. (1996). Total Knee Arthroplasty: Knee Replacement Surgery. Akron, OH: Rehabilitation and Health Center.
Hart, F., Taylor, R., and Huskisson, E. (1970). Pain at night. Lancet 1: 881–884.
Jakobsson, U., Klevsgard, R., Westergren, A., et al. (2003). Old people in pain: A comparative study. J. Pain Symptom Manage. 26: 625–636.
Kain, Z., and Caldwell-Andrews, A. A. (2003). Sleeping characteristics of adults undergoing outpatient elective surgery: A cohort study. J. Clin. Anesth. 15: 505–509.
Kehlet, H. (1991). The surgical stress response: Should it be prevented? Can. J. Surg.34: 565–567.
Lingard, E. A., Katz, J. N., Wright, E. A., and Sledge, C. B. (2004). Predicting the outcome of total knee arthroplasty. J. Bone Joint Surg. 86: 2179–2186.
MacKinnon, D. P., Lockwood, C. M., Hoffman, J. M., West, S. G., and Sheets, V. (2002). A comparison of methods to test mediation and other intervening variable effects. Psychol. Methods 7: 83–104.
McCracken, L. M., and Iverson, G. L. (2002). Disrupted sleep patterns and daily functioning in patients with chronic pain. Pain Res. Manage. 7: 75–79.
Meenan, R. F., Mason, J. H., Anderson, J. J., Guccione, A. A., and Kazis, L. E. (1992). The content and properties of a revised and expanded arthritis impact measurement scales health status questionnaire. Arthritis Rheum. 35: 1–10.
Morin, C. M., Gibson, D., and Wade, J. (1998). Self-reported sleep and mood disturbance in chronic pain patients. Clin. J. Pain 14: 311–314.
Nicassio, P. M., and Wallston, K. A. (1992). Longitudinal relationships among pain, sleep problems, and depression in rheumatoid arthritis. J. Abnorm. Psychol. 101: 514–520.
Pilowsky, I., Crettenden, I., and Townley, M. (1985). Sleep disturbance in pain clinic patients. Pain 23: 27–33.
Radloff, L. S. (1977). The CES-D scale: A self-report depression scale for research in the general population. Appl. Psychol. Meas. 1: 385–401.
Raymond, I., Nielsen, T. A., Lavigne, G., et al. (2001). Quality of sleep and its daily relationship to pain intensity in hospitalized adult burn patients. Pain 92: 381–388.
Rohr. W.L., and Hungerford, D.S. (1992). Primary Totl Knee Arthroplasty. Operative Orthopaedics, 2, 1-16.
Scudds, R. J., and Robertson, J. M. (1998). Empirical evidence of the association between the presence of musculoskeletal pain and physical disability in community-dwelling senior citizens. Pain 75: 229–235.
Stepnowsky, C., Johnson, S., Dimsale, J., and Ancoli-Israel, S. (2000). Sleep apnea and health-related quality of life in African-American elderly. Ann. Behav. Med.22: 116–120.
ACKNOWLEDGMENTS
This study was supported by a grant from the Center for the Treatment and Study of Traumatic Stress, Kent State University and Summa Health System. Preparation of this manuscript was supported, in part, by National Institutes of Mental Health grants R01 MH 62042 and R34 MH073012.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Cremeans-Smith, J.K., Millington, K., Sledjeski, E. et al. Sleep Disruptions Mediate the Relationship Between Early Postoperative Pain and Later Functioning Following Total Knee Replacement Surgery. J Behav Med 29, 215–222 (2006). https://doi.org/10.1007/s10865-005-9045-0
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10865-005-9045-0