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Protective effects of resveratrol on calcium-induced oxidative stress in rat heart mitochondria

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Abstract

Trans-resveratrol is a nutraceutical with known antioxidant, anti-inflammatory, cardioprotective, and anti-apoptotic properties. The aim of this study was to evaluate the effects of resveratrol on heart mitochondria. Resveratrol significantly decreased Fe2+ + ascorbate oxidant system-induced lipid peroxide levels, preserved physiological levels of glutathione, and increased nitric oxide (NO) levels in mitochondria. Under calcium-mediated stress, there was a 2.7-fold increase in the NO levels, and a mild decoupling in the mitochondrial respiratory chain. These results provide a mechanism for and support the beneficial effects of resveratrol under pathological conditions induced by oxidative stress and calcium overload. In addition, these findings underscore the usefulness of resveratrol in the prevention of cardiovascular diseases.

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Authors and Affiliations

  1. Edificio B-3. C.U., Instituto de Investigaciones Químico-Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, Morelia, Mich., México

    Alfredo Saavedra-Molina

  2. Facultad de Enfermería, Universidad Michoacana de San Nicolás de Hidalgo, Morelia, Mich., México

    Elizabeth Calderón-Cortés

  3. University of Texas Medical Branch at Galveston, School of Medicine, Galveston, TX, USA

    Istvan Boldogh & Alfredo Saavedra-Molina

  4. Instituto de Investigaciones Químico-Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, Morelia, Mich., México

    Areli Gutiérrez-Pérez, Christian Cortés-Rojo, Ruth Noriega-Cisneros, Salvador Manzo-Avalos, Mónica Clemente-Guerrero & Daniel Godínez-Hernández

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  1. Areli Gutiérrez-Pérez
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  2. Christian Cortés-Rojo
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  3. Ruth Noriega-Cisneros
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  4. Elizabeth Calderón-Cortés
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  5. Salvador Manzo-Avalos
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  6. Mónica Clemente-Guerrero
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  7. Daniel Godínez-Hernández
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  8. Istvan Boldogh
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  9. Alfredo Saavedra-Molina
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Correspondence to Alfredo Saavedra-Molina.

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Gutiérrez-Pérez, A., Cortés-Rojo, C., Noriega-Cisneros, R. et al. Protective effects of resveratrol on calcium-induced oxidative stress in rat heart mitochondria. J Bioenerg Biomembr 43, 101–107 (2011). https://doi.org/10.1007/s10863-011-9349-4

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  • DOI: https://doi.org/10.1007/s10863-011-9349-4

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