Skip to main content
SpringerLink
Log in

ATP Synthases With Novel Rotor Subunits: New Insights into Structure, Function and Evolution of ATPases

  • Published:
Journal of Bioenergetics and Biomembranes Aims and scope Submit manuscript

 

ATPases with unusual membrane-embedded rotor subunits were found in both F1F0 and A1A0 ATP synthases. The rotor subunit c of A1A0 ATPases is, in most cases, similar to subunit c from F0. Surprisingly, multiplied c subunits with four, six, or even 26 transmembrane spans have been found in some archaea and these multiplication events were sometimes accompanied by loss of the ion-translocating group. Nevertheless, these enzymes are still active as ATP synthases. A duplicated c subunit with only one ion-translocating group was found along with “normal” F0 c subunits in the Na+ F1F0 ATP synthase of the bacterium Acetobacterium woodii. These extraordinary features and exceptional structural and functional variability in the rotor of ATP synthases may have arisen as an adaptation to different cellular needs and the extreme physicochemical conditions in the early history of life.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Aufurth, S., Schägger, H., and Müller, V. (2000). J. Biol. Chem. 275, 33297–33301.

    Article  CAS  Google Scholar 

  • Becher, B., and Müller, V. (1994). J. Bacteriol. 176, 2543–2550.

    CAS  Google Scholar 

  • Coskun, Ü., Grüber, G., Koch, M. H., Godovac-Zimmermann, J., Lemker, T., and Müller, V. (2002). J. Biol. Chem. 277, 17327–17333.

    Article  CAS  Google Scholar 

  • Coskun, Ü., Radermacher, M., Müller, V., Ruiz, T., and Grüber, G. (2004). J. Biol. Chem. 279, 22759–22764.

    Article  CAS  Google Scholar 

  • Cross, R. L., and Müller, V. (2004). FEBS Lett. 576, 1–4.

    Article  CAS  Google Scholar 

  • Forster, A., Daniel, R., and Müller, V. (1995). Biochim. Biophys. Acta. 1229, 393–397.

    Article  Google Scholar 

  • Grüber, G., Svergun, D. I., Coskun, Ü., Lemker, T., Koch, M. H., Schägger, H., and Müller, V. (2001a). Biochemistry 40, 1890–1896.

    Article  CAS  Google Scholar 

  • Grüber, G., Wieczorek, H., Harvey, W. R., and Müller, V. (2001b). J. Exp. Biol. 204, 2597–2605.

    Google Scholar 

  • Hendrickson, E. L., Kaul, R., Zhou, Y., Bovee, D., Chapman, P., Chung, J., Conway de Macario, E., Dodsworth, J. A., Gillett, W., Graham, D. E., Hackett, M., Haydock, A. K., Kang, A., Land, M. L., Levy, R., Lie, T. J., Major, T. A., Moore, B. C., Porat, I., Palmeiri, A., Rouse, G., Saenphimmachak, C., Soll, D., Van Dien, S., Wang, T., Whitman, W. B., Xia, Q., Zhang, Y., Larimer, F. W., Olson, M. V., and Leigh, J. A. (2004). J. Bacteriol. 186, 6956–6969.

    Article  CAS  Google Scholar 

  • Hilario, E., and Gogarten, J. P. (1998). J. Mol. Evol. 46, 703–715.

    Article  CAS  Google Scholar 

  • Ihara, K., Watanabe, S., Sugimura, K., and Mukohata, Y. (1997). Arch. Biochem. Biophys. 341, 267–272.

    Article  CAS  Google Scholar 

  • Inatomi, K. I., Maeda, M., and Futai, M. (1989). Biochem. Biophys. Res. Commun. 162, 1585–1590.

    Article  CAS  Google Scholar 

  • Kane, P. M., and Smardon, A. M. (2003). J. Bioenerg. Biomembr. 35, 313–321.

    Article  CAS  Google Scholar 

  • Kawasaki-Nishi, S., Nishi, T., and Forgac, M. (2001). Proc. Natl. Acad. Sci. U.S.A. 98, 12397–12402.

    Article  CAS  Google Scholar 

  • Lemker, T., Ruppert, C., Stöger, H., Wimmers, S., and Müller, V. (2001). Eur. J. Biochem. 268, 3744–3750.

    Article  CAS  Google Scholar 

  • Lemker, T., Grüber, G., Schmid, R., and Müller, V. (2003). FEBS Lett. 544, 206–209.

    Article  CAS  Google Scholar 

  • Lingl, A., Huber, H., Stetter, K. O., Mayer, F., Kellermann, J., and Müller, V. (2003). Extremophiles 7, 249–257.

    CAS  Google Scholar 

  • Müller, V., Ruppert, C., and Lemker, T. (1999). J. Bioenerg. Biomembr. 31, 15–28.

    Article  Google Scholar 

  • Müller, V., Aufurth, S., and Rahlfs, S. (2001). Biochim. Biophys. Acta. 1505, 108–120.

    Article  Google Scholar 

  • Müller, V. (2003). Appl. Environ. Microbiol. 69, 6345–6353.

    Article  CAS  Google Scholar 

  • Müller, V., and Grüber, G. (2003). Cell. Mol. Life Sci. 60, 474–494.

    Article  Google Scholar 

  • Müller, V. (2004). J. Bioenerg. Biomembr. 36, 115–125.

    Article  Google Scholar 

  • Nelson, N., and Taiz, L. (1989). Trends Biochem. Sci. 14, 113–116.

    Article  CAS  Google Scholar 

  • Rahlfs, S., Aufurth, S., and Müller, V. (1999). J. Biol. Chem. 274, 33999–34004.

    Article  CAS  Google Scholar 

  • Reidlinger, J., and Müller, V. (1994). Eur. J. Biochem. 223, 275– 283.

    Article  CAS  Google Scholar 

  • Robb, F. T., Maeder, D. L., Brown, J. R., DiRuggiero, J., Stump, M D., Yeh, R. K., Weiss, R. B., and Dunn, D. M. (2001). Methods Enzymol. 330, 134–157.

    Article  CAS  Google Scholar 

  • Ruppert, C., Wimmers, S., Lemker, T., and Müller, V. (1998). J. Bacteriol. 180, 3448–3452.

    CAS  Google Scholar 

  • Ruppert, C., Kavermann, H., Wimmers, S., Schmid, R., Kellermann, J., Lottspeich, F., Huber, H., Stetter, K. O., and Müller, V. (1999). J. Biol. Chem. 274, 25281–25284.

    Article  CAS  Google Scholar 

  • Sapra, R., Bagramyan, K., and Adams, M. W. (2003). Proc. Natl. Acad. Sci. U.S.A. 100, 7545–7550.

    Article  CAS  Google Scholar 

  • Schäfer, G., and Meyering-Vos, M. (1992). Biochim. Biophys. Acta 1101, 232–235.

    Google Scholar 

  • Schäfer, G., Engelhard, M., and Müller, V. (1999). Microbiol. Mol. Biol. Rev. 63, 570–620.

    Google Scholar 

  • Schemidt, R. A., Qu, J., Williams, J. R., and Brusilow, W. S. (1998). J. Bacteriol. 180, 3205–3208.

    CAS  Google Scholar 

  • Slesarev, A. I., Mezhevaya, K. V., Makarova, K. S., Polushin, N. N., Shcherbinina, O. V., Shakhova, V. V., Belova, G. I., Aravind, L., Natale, D. A., Rogozin, I. B., Tatusov, R. L., Wolf, Y. I., Stetter, K. O., Malykh, A. G., Koonin, E. V., and Kozyavkin, S. A. (2002). Proc. Natl. Acad. Sci. U.S.A. 99, 4644– 4649.

    Article  CAS  Google Scholar 

  • Steinert, K., Wagner, V., Kroth-Pancic, P. G., and Bickel-Sandkötter, S. (1997). J. Biol. Chem. 272, 6261–6269.

    Article  CAS  Google Scholar 

  • Wilms, R., Freiberg, C., Wegerle, E., Meier, I., Mayer, F., and Müller, V. (1996). J. Biol. Chem. 271, 18843– 18852.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Molecular Microbiology & Bioenergetics, Institute of Molecular Biosciences, Johann Wolfgang Goethe University, Frankfurt, Germany

    Volker Müller, Astrid Lingl, Kim Lewalter & Michael Fritz

Authors
  1. Volker Müller
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Astrid Lingl
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Kim Lewalter
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Michael Fritz
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Volker Müller.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Müller, V., Lingl, A., Lewalter, K. et al. ATP Synthases With Novel Rotor Subunits: New Insights into Structure, Function and Evolution of ATPases. J Bioenerg Biomembr 37, 455–460 (2005). https://doi.org/10.1007/s10863-005-9491-y

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10863-005-9491-y

Key Words

Search

Navigation