Skip to main content
SpringerLink
Log in

Physiological and Metabolic Implications of V-ATPase Isoforms in the Kidney

  • Published:
Journal of Bioenergetics and Biomembranes Aims and scope Submit manuscript

 

Not all vacuolar-type H+-ATPases (V-ATPases) are alike; those responsible for H+ movement across plasma membranes contain some different, tissue-specific subunit isoforms. This brief review outlines those that have special relevance to the kidney, and illustrates their importance by describing various human diseases where loss of local proton pump function not only confers a severe phenotype, but has revealed related tissues where these same isoforms are expressed, signifying their physiological importance.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Butler, A. M., Wilson, J. L., and Farber, S. (1936). J. Pediatr. 8, 489.

    Article  Google Scholar 

  • Dou, H., Xu, J., Wang, Z., Smith, A. N., Soleimani, M., Karet, F. E., Greinwald, J. H., Jr., and Choo, D. (2004). J. Histochem. Cytochem. 52, 1377–1384.

    Article  CAS  Google Scholar 

  • Finberg, K. E., Wagner, C. A., Bailey, M. A., Paunescu, T. G., Breton, S., Brown, D., Giebisch, G., Geibel, J. P., and Lifton, R. P. (2005). Proc. Natl. Acad. Sci. USA. 102, 13616–13621.

    Google Scholar 

  • Gillespie, J., Ozanne, S., Tugal, B., Percy, J., Warren, M., Haywood, J., and Apps, D. (1991). FEBS Lett. 282, 69–72.

    Article  CAS  Google Scholar 

  • Gluck, S., and Caldwell, J. (1988). Am. J. Physiol. 254, F71–F79.

    CAS  Google Scholar 

  • Kane, P. M. (1995). J. Biol. Chem. 270, 17025–17032.

    CAS  Google Scholar 

  • Karet, F. E. (2002). J. Am. Soc. Nephrol. 13, 2178–2184.

    Article  CAS  Google Scholar 

  • Karet, F. E., Finberg, K. E., Nelson, R. D., Nayir, A., Mocan, H., Sanjad, S. A., Rodriguez-Soriano, J., Santos, F., Cremers, C. W., Di Pietr., A., Hoffbrand, B. I., Winiarski, J., Bakkaloglu, A., Ozen, S., Dusunsel, R., Goodyer, P., Hulton, S. A., Wu, D. K., Skvorak, A. B., Morton, C. C., Cunningham, M. J., Jha, V., and Lifton, R. P. (1999). Nat. Genet. 21, 84–90.

    Article  CAS  Google Scholar 

  • Leng, X. H., Manolson, M. F., and Forgac, M. (1998). J. Biol. Chem. 273, 6717–6723.

    Article  CAS  Google Scholar 

  • Lightwood, R. (1935). Arch. Dis. Child. 10, 205.

    Article  Google Scholar 

  • Lu, M., Holliday, L. S., Zhang, L., Dunn, W. A., Jr., and Gluck, S. L. (2001). J. Biol. Chem. 276, 30407–30413.

    Article  CAS  Google Scholar 

  • Lu, M., Sautin, Y. Y., Holliday, L. S., and Gluck, S. L. (2004). J. Biol. Chem. 279, 8732–8739.

    Article  CAS  Google Scholar 

  • Nishi, T., and Forgac, M. (2002). Nat. Rev. Mol. Cell Biol. 3, 94–103.

    Article  CAS  Google Scholar 

  • Paunescu, T. G., Da Silva, N., Marshansky, V., McKee, M., Breton, S., and Brown, D. (2004). Am. J. Physiol. Cell Physiol. 287, C149–C162.

    Article  CAS  Google Scholar 

  • Peces, R. (2000). Pediatr. Nephrol. 15, 63–65.

    Article  CAS  Google Scholar 

  • Santos, F., and Chan, J. C. (1986). Am. J. Nephrol. 6, 289–295.

    Article  CAS  Google Scholar 

  • Smith, A. N., Borthwick, K. J., and Karet, F. E. (2002). Gene 297, 169–177.

    Article  CAS  Google Scholar 

  • Smith, A. N., Skaug, J., Choate, K. A., Nayir, A., Bakkaloglu, A., Ozen, S., Hulton, S. A., Sanjad, S. A., Al-Sabban, E. A., Lifton, R. P., Scherer, S. W., and Karet, F. E. (2000). Nat. Genet. 26, 71–75.

    Article  CAS  Google Scholar 

  • Stover, E. H., Borthwick, K. J., Bavalia, C., Eady, N., Fritz, D. M., Rungroj, N., Giersch, A. B., Morton, C. C., Axon, P. R., Akil, I., Al-Sabban, E. A., Baguley, D. M., Bianca, S., Bakkaloglu, A., Bircan, Z., Chauveau, D., Clermont, M. J., Guala, A., Hulton, S. A., Kroes, H., Li Volti, G., Mir, S., Mocan, H., Nayir, A., Ozen, S., Rodriguez Soriano, J., Sanjad, S. A., Tasic, V., Taylor, C. M., Topaloglu, R., Smith, A. N., and Karet, F. E. (2002). J. Med. Genet. 39, 796–803.

    Article  CAS  Google Scholar 

  • Su, Y., Zhou, A., Al-Lamki, R. S., and Karet, F. E. (2003). J. Biol. Chem. 278, 20013–20018.

    Article  CAS  Google Scholar 

  • Sun-Wada, G. H., Murata, Y., Namba, M., Yamamoto, A., Wada, Y., and Futai, M. (2003a). J. Biol. Chem. 278, 44843–44851.

    Article  CAS  Google Scholar 

  • Sun-Wada, G. H., Yoshimizu, T., Imai-Senga, Y., Wada, Y., and Futai, M. (2003b). Gene 302, 147–153.

    Article  CAS  Google Scholar 

  • van Hille, B., Richener, H., Schmid, P., Puettner, I., Green, J. R., and Bilbe, G. (1994). Biochem. J. 303(Pt 1), 191–198.

    CAS  Google Scholar 

  • Wax, M. B., Saito, I., Tenkova, T., Krupin, T., Becker, B., Nelson, N., Brown, D., and Gluck, S. L. (1997). Proc. Natl. Acad. Sci. U.S.A. 94, 6752–6757.

    Google Scholar 

  • Wrong, O., and Davies, H. E. (1959). Q. J. Med. 28, 259–313.

    CAS  Google Scholar 

  • Zakzouk, S. M., Sobki, S. H., Mansour. F., and al Anazy, F. H. (1995). J. Laryngol. Otol. 109, 930–934.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Renal Medicine and Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Box 139, Addenbrooke’s Hospital, Hills Road, Cambridge, CB2 2XY, UK

    Fiona E. Karet

Authors
  1. Fiona E. Karet
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Fiona E. Karet.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Karet, F.E. Physiological and Metabolic Implications of V-ATPase Isoforms in the Kidney. J Bioenerg Biomembr 37, 425–429 (2005). https://doi.org/10.1007/s10863-005-9484-x

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10863-005-9484-x

Key Words

Search

Navigation