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Keratin nanoparticles-coating electrospun PVA nanofibers for potential neural tissue applications

  • Engineering and Nano-engineering Approaches for Medical Devices
  • Original Research
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Abstract

Keratin has the potential to improve biocompatibility and bioactivity of polymeric nanofibers. However, the addition of keratin into the blend nanofiber would decrease the mechanical properties of nanofibers due to the poor spinnability of keratin, and caused inhomogeneous distribution of keratin inside the nanofibers. Therefore, polymeric nanofibers surface-modified with keratin nanoparticles would improve the hydrophility and mechanical property. In this study, keratose (oxidative keratin, KOS) nanoparticles-coating PVA nanofibers (KNPs/PVA) were fabricated by electrospray deposition after electrospinning and acted on neural cells. The chemical conformation, mechanical properties and wettability of KNPs/PVA nanofibers were characterized. The KNPs/PVA nanofibers provided better wettability and stronger mechanical properties compared to KOS/PVA blend nanofibers at the same mass ratio of KOS to PVA. Furthermore, KNPs/PVA nanofibers displayed better cyto-biocompatibility in terms of cell morphology, adhesion and proliferation compared with PVA nanofibers and KOS/PVA blend nanofibers. These results suggested that polymeric nanofibers surface-modified with KOS nanoparticles can provide superior wettability, mechanical properties and biocompatibility by comparison with the blend nanofibers.

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Acknowledgements

The authors acknowledge the financial assistance provided by the National Natural Science Foundation of China [Grant No. 31600770], Chongqing Research Program of Basic Research and Frontier Technology (Grant No. cstc2018jcyjAX0836), and the Fundamental Research Funds for the Central Universities [Grant Nos. 106112017CDJXY230006 and 106112018CDQYSG0007].

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Authors and Affiliations

  1. Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, 400030, China

    Tingwang Guo, Liancai Zhu, Bochu Wang & Shilei Hao

  2. College of Environment and Resources, Chongqing Technology and Business University, Chongqing, 400067, China

    Tingwang Guo & Jia Deng

  3. Medical Technology Department, Dehong Vocational College, Dehong, 678400, Yunnan, China

    Xin Yang

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  1. Tingwang Guo
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Correspondence to Liancai Zhu, Bochu Wang or Shilei Hao.

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Guo, T., Yang, X., Deng, J. et al. Keratin nanoparticles-coating electrospun PVA nanofibers for potential neural tissue applications. J Mater Sci: Mater Med 30, 9 (2019). https://doi.org/10.1007/s10856-018-6207-5

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