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Redox poly(ethylene glycol)-b-poly(l-lactide) micelles containing diselenide bonds for effective drug delivery

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Abstract

Bioreducible polymers have appeared as the ideal drug carriers for tumor therapy due to their properties of high stability in extracellular circulation and rapid drug release in intracellular reducing environment. Recently, the diselenide bond has emerged as a new reduction-sensitive linkage. In this work, the amphiphilic poly(ethylene glycol)-b-poly(l-lactide) containing diselenide bond has been synthesized and used to load anti-tumor drug, docetaxel (DTX), to form the redox micelles. It was found that the redox micelles showed a rapid response to glutataione (GSH), which resulted in a fast release of DTX in the presence of GSH. In contrast, <40 % of DTX was released from the micelles within 72 h under the normal condition (absence of GSH). The DTX-loaded redox micelles showed the significant inhibition effect to MCF-7 cells, and the cytotoxicity was dependent on the intracellular GSH concentrations. Moreover, considering the potentially clinical applications of the micelles through intravenous injection, the blood compatibility was also studied by the hemolysis analysis, activated partial thromboplastin time, prothrombin time and thromboelastography assays. These results confirmed that the redox micelles showed good blood safety, suggesting a potential application in tumor therapy.

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Acknowledgments

This work was financially supported by National Natural Science Foundation of China (31271019), Natural Science Foundation of Guangdong Province (2014A030313361 and S2013010013452) as well as the Fundamental Research Funds for the Central Universities.

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Authors and Affiliations

  1. Key Laboratory of Biomaterials of Guangdong Higher Education Institutes, Department of Biomedical Engineering, Jinan University, Guangzhou, 510632, China

    Xiaolong Zeng, Xiaoyan Zhou, Mengyi Li, Changyong Wang, Dong Ma & Wei Xue

  2. Department of Advanced Interdisciplinary Studies, Institute of Basic Medical Sciences and Tissue Engineering Research Center, Academy of Military Medical Sciences, Beijing, 100850, China

    Changyong Wang

  3. School of Pathology and Laboratory Medicine, University of Western Australia, Perth, Australia

    Jiake Xu

  4. Institute of Life and Health Engineering, Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, Jinan University, Guangzhou, 510632, China

    Wei Xue

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  1. Xiaolong Zeng
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Correspondence to Dong Ma or Wei Xue.

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Zeng, X., Zhou, X., Li, M. et al. Redox poly(ethylene glycol)-b-poly(l-lactide) micelles containing diselenide bonds for effective drug delivery. J Mater Sci: Mater Med 26, 234 (2015). https://doi.org/10.1007/s10856-015-5573-5

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