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Human mesenchymal stem cell response to poly(ε-caprolactone/poly(methyl methacrylate) demixed thin films

  • Special Issue: ESB 2014
  • Biocompatibility Studies
  • Published:
Journal of Materials Science: Materials in Medicine Aims and scope Submit manuscript

Abstract

Advances in material sciences have enabled the fabrication of biomaterials which are able to provide the requisite cues to stimulate cells to behave in a specific way. Nanoscale surface topographies are well known to be able to positively influence cell–substrate interactions. This study reports on a novel series of poly(ε-caprolactone) PCL and poly(methyl methacrylate) demixed nanotopographic films as non-biological cell-stimulating cues. The topographic features observed ranged from nanoislands to nanopits. PMMA was observed to segregate to the air interface, while PCL preferred the substrate interface. Preliminary response of human mesenchymal stem cells to these surfaces indicated that the substrate with nanoisland topography has the potential to differentiate to osteogenic, chondrogenic and adipogenic lineages.

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Acknowledgments

The authors wish to thank Dr. Riaz Akhtar for the use of the AFM. This study was supported by the use of resources at the School of Engineering and the Institute of Aging and Chronic Disease.

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Authors and Affiliations

  1. Centre for Materials and Structures, University of Liverpool, Brownlow Hill, Liverpool, L69 3GH, UK

    Mohammed Khattak, Judith M. Curran & Raechelle A. D’Sa

  2. Department of Clinical Engineering, UK Centre for Tissue Engineering, Daulby Street, Liverpool, L69 3GA, UK

    Fanrong Pu & John A. Hunt

Authors
  1. Mohammed Khattak
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  2. Fanrong Pu
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  3. Judith M. Curran
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  4. John A. Hunt
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  5. Raechelle A. D’Sa
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Correspondence to Raechelle A. D’Sa.

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Khattak, M., Pu, F., Curran, J.M. et al. Human mesenchymal stem cell response to poly(ε-caprolactone/poly(methyl methacrylate) demixed thin films. J Mater Sci: Mater Med 26, 178 (2015). https://doi.org/10.1007/s10856-015-5507-2

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  • DOI: https://doi.org/10.1007/s10856-015-5507-2

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