Skip to main content

Advertisement

SpringerLink
Log in

Wound healing activity of Origanum vulgare engineered titanium dioxide nanoparticles in Wistar Albino rats

  • Published:
Journal of Materials Science: Materials in Medicine Aims and scope Submit manuscript

Abstract

The titanium dioxide nanoparticles (TiO2·NPs) were synthesized utilizing Origanum vulgare under room temperature. The green synthesized TiO2 NPs excitation was confirmed using UV–Vis spectrophotometer at 320 nm. Scanning electron microscopy analysis showed TiO2·NPs are spherical in shape and connected with one another. Dynamic light scattering analysis results specified high stability in nanoparticles, with an average particle size of 341 nm. Fourier transform infrared spectroscopy peaks revealed the presence of bioactive functional groups in Origanum vulgare aqueous leaf extract much needed for the TiO2·NPs formation. X-ray diffraction spectra showed the TiO2·NPs are amorphous in nature. Furthermore, the green synthesized TiO2·NPs wound healing activity was examined in the excision wound model by measuring wound closure, histopathology and protein profiling, revealed significant wound healing activity in Albino rats. In conclusion, our results bared TiO2·NPs have delivered a novel therapeutic route for wound treatment in clinical practice.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8

Similar content being viewed by others

References

  1. Bansal V, Bharde A, Ramanathan R, Bhargava SK. Inorganic materials using ‘unusual’ microorganisms. Adv Colloid Interface Sci. 2012;150:179–82.

    Google Scholar 

  2. Galdiero S, Falanga A, Vitiello M, Cantisani M, Marra V, Galdiero M. Silver nanoparticles as potential antiviral agents. Molecules. 2011;16:8894–918.

    Article  Google Scholar 

  3. Syed A, Ahmad A. Extracellular biosynthesis of platinum nanoparticles using the fungus Fusarium oxysporum. Colloids Surf B. 2012;97:27–31.

    Article  Google Scholar 

  4. Sankar R, Manikandan P, Malarvizhi V, Fathima T, Shivashangari KS, Ravikumar V. Green synthesis of colloidal copper oxide nanoparticles using Carica papaya and its application in photocatalytic dye degradation. Spectrochim. Acta A. 2014;121:746–50.

    Article  Google Scholar 

  5. Tayade RJ, Surolia PK, Kulkarni RG, Jasr RV. Photocatalytic degradation of dyes and organic contaminants in water using nanocrystalline anatase and rutile TiO2. Sci Tech Adv Mater. 2007;8:455.

    Article  Google Scholar 

  6. Sudha S, Sankar R, Saradhai P. Antibiogram pattern of bacterial pathogens isolated from post operative surgical site wound infections. Drug Invent. Today. 2012;4:575–8.

    Google Scholar 

  7. Guo S, Dipietro LA. Factors affecting wound healing. J Dent Res. 2010;89:219–29.

    Article  Google Scholar 

  8. Chou TH, Ding HY, Hung WJ, Liang CH. Antioxidative characteristics and inhibition of alpha-melanocyte-stimulating hormone-stimulated melanogenesis of vanillin and vanillic acid from Origanum vulgare. Exp Dermatol. 2010;19:742–50.

    Article  Google Scholar 

  9. Sankar R, Karthik A, Prabu A, Karthik S, Shivashangari KS, Ravikumar V. Origanum vulgare mediated biosynthesis of silver nanoparticles for its antibacterial and anticancer activity. Colloids Surf B. 2013;108:80–4.

    Article  Google Scholar 

  10. Ponrasu T, Suguna L. Efficacy of annona squamosa on wound healing in streptozotocin-induced diabetic rats. Int Wound J. 2012;9:613–23.

    Article  Google Scholar 

  11. Sasidharan S, Logeswaran S, Latha LY. Wound healing activity of elaeis guineensis leaf extract ointment. Int J Mol Sci. 2012;13:336–47.

    Article  Google Scholar 

  12. Su-Mi Lee, Shin-Won Kang, Dong-Uk Kim, Jian-Zhong Cui, Sung-Hoon Kim. Effect of metal ions on the absorption spectra and surface plasmon resonance of an azacrown indoaniline dye. Dyes Pigment. 2001;49:109–15.

    Article  Google Scholar 

  13. Prakash P, Gnanaprakasam P, Emmanuel R, Arokiyaraj S, Saravanan M. Green synthesis of silver nanoparticles from leaf extract of Mimusops elengi, Linn. for enhanced antibacterial activity against multi drug resistant clinical isolates. Colloids Surf. B. 2013;1:255–9.

    Article  Google Scholar 

  14. Sedghi A, Miankushki HN. Influence of TiO2 electrode properties on performance of dye-sensitized solar cells. Int J Electrochem Sci. 2012;7:12078–89.

    Google Scholar 

  15. Suttiponparnit K, Jiang J, Sahu M, Suvachittanont S, Charinpanitkul T, Biswas P. Role of surface area, primary particle size, and crystal phase on titanium dioxide nanoparticle dispersion properties. Nanoscale Res Lett. 2011. doi:10.1007/s11671-010-9772-1.

    Google Scholar 

  16. Bihari P, Vippola M, Schultes S, Praetner M, Khandoga AG, Reichel CA, Coester C, Tuomi T, Rehberg M, Krombach F. Optimized dispersion of nanoparticles for biological in vitro and in vivo studies. Part Fibre Toxicol. 2008. doi:10.1186/1743-8977-5-14.

    Google Scholar 

  17. Bidgoli SA, Mahdavi M, Rezayat SM, Korani M, Amani A, Ziarati P. Toxicity assessment of nanosilver wound dressing in Wistar rat. Acta Med Iran. 2013;7:203–8.

    Google Scholar 

  18. Tian J, Wong KK, Ho CM, Lok CN, Yu WY, Che CM, Chiu JF, Tam PK. Topical delivery of silver nanoparticles promotes wound healing. ChemMedChem. 2007;2:129–36.

    Article  Google Scholar 

  19. Wilkinson LJ, White RJ, Chipman JK. Silver and nanoparticles of silver in wound dressings: a review of efficacy and safety. J Wound Care. 2011;20:543–9.

    Article  Google Scholar 

  20. Atiyeh BS, Costagliola M, Hayek SN, Dibo SA. Effect of silver on burn wound infection control and healing: review of the literature. Burns. 2007;33:139–48.

    Article  Google Scholar 

  21. Cortivo R, Vindigni V, Iacobellis L, Abatangelo G, Pinton P, Zavan B. Nanoscale particle therapies for wounds and ulcers. Nanomedicine Lond. 2010;5:641–56.

    Article  Google Scholar 

Download references

Acknowledgments

We are grateful to Department of Science and Technology (DST) for providing financial assistance to Mr. Renu Sankar through INSPIRE Fellowship scheme. We extend our acknowledgement to the University Grant Commission (UGC), Science & Engineering Research Board (SERB) for their financial support. We also thank Department of Science and Technology—Fund for Improvement of S & T Infrastructure in Universities and Higher Educational Institutions (DST-FIST) for their infrastructure support to our department.

Author information

Authors and Affiliations

  1. Department of Biochemistry, School of Life Science, Bharathidasan University, Tiruchirappalli, 620 024, Tamilnadu, India

    Renu Sankar, Ravishankar Dhivya & Vilwanathan Ravikumar

  2. Regional Forensic Science Laboratory, Tiruchirapalli, Tamilnadu, India

    Kanchi Subramanian Shivashangari

Authors
  1. Renu Sankar
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ravishankar Dhivya
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Kanchi Subramanian Shivashangari
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Vilwanathan Ravikumar
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Kanchi Subramanian Shivashangari or Vilwanathan Ravikumar.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sankar, R., Dhivya, R., Shivashangari, K.S. et al. Wound healing activity of Origanum vulgare engineered titanium dioxide nanoparticles in Wistar Albino rats. J Mater Sci: Mater Med 25, 1701–1708 (2014). https://doi.org/10.1007/s10856-014-5193-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10856-014-5193-5

Keywords

Search

Navigation