Skip to main content

Advertisement

SpringerLink
Log in

Bone ingrowth potential of electron beam and selective laser melting produced trabecular-like implant surfaces with and without a biomimetic coating

  • Published:
Journal of Materials Science: Materials in Medicine Aims and scope Submit manuscript

Abstract

The bone ingrowth potential of trabecular-like implant surfaces produced by either selective laser melting (SLM) or electron beam melting (EBM), with or without a biomimetic calciumphosphate coating, was examined in goats. For histological analysis and histomorphometry of bone ingrowth depth and bone implant contact specimens were implanted in the femoral condyle of goats. For mechanical push out tests to analyse mechanical implant fixation specimens were implanted in the iliac crest. The follow up periods were 4 (7 goats) and 15 weeks (7 goats). Both the SLM and EBM produced trabecular-like structures showed a variable bone ingrowth after 4 weeks. After 15 weeks good bone ingrowth was found in both implant types. Irrespective to the follow up period, and the presence of a coating, no histological differences in tissue reaction around SLM and EBM produced specimens was found. Histological no coating was detected at 4 and 15 weeks follow up. At both follow up periods the mechanical push out strength at the bone implant interface was significantly lower for the coated SLM specimens compared to the uncoated SLM specimens. The expected better ingrowth characteristics and mechanical fixation strength induced by the coating were not found. The lower mechanical strength of the coated specimens produced by SLM is a remarkable result, which might be influenced by the gross morphology of the specimens or the coating characteristics, indicating that further research is necessary.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6

Similar content being viewed by others

References

  1. Basarir K, Erdemli B, Can A, Erdemli E, Zeyrek T. Osseointegration in arthroplasty: can simvastatin promote bone response to implants? Int Orthop. 2009;33(3):855.

    Article  Google Scholar 

  2. Karageorgiou V, Kaplan D. Porosity of 3D biomaterial scaffolds and osteogenesis. Biomaterials. 2005;26(27):5474.

    Article  CAS  Google Scholar 

  3. Kaplan FS, Lee WC, Keaveny TM. Forms and functions of bone. p. 127. In: Simon SP, editor. Orthopedic basic science. Columbus: American Academy of Orthopedic Surgeons; 1994.

    Google Scholar 

  4. Keaveny TM, Morgan EF, Niebur GL, Yeh OC. Biomechanics of trabecular bone. Annu Rev Biomed Eng. 2001;3:307.

    Article  CAS  Google Scholar 

  5. Bobyn JD, Stackpool GJ, Hacking SA, Tanzer M, Krygier JJ. Characteristics of bone ingrowth and interface mechanics of a new porous tantalum biomaterial. J Bone Joint Surg Br. 1999;81(5):907.

    Article  CAS  Google Scholar 

  6. Murr LE, Quinones SA, Gaytan SM, Lopez MI, Rodela A, Martinez EY, Hernandez DH, Martinez E, Medina F, Wicker RB. Microstructure and mechanical behavior of Ti-6Al-4V produced by rapid-layer manufacturing, for biomedical applications. J Mech Behav Biomed Mater. 2009;2(1):20.

    Article  CAS  Google Scholar 

  7. Fukuda A, Takemoto M, Saito T, Fujibayashi S, Neo M, Pattanayak DK, Matsushita T, Sasaki K, Nishida N, Kokubo T, Nakamura T. Osteoinduction of porous Ti implants with a channel structure fabricated by selective laser melting. Acta Biomater. 2011;7(5):2327.

    Article  CAS  Google Scholar 

  8. Noort Van. The future of dental devices is digital. Dent Mater. 2012;28(1):3.

    Article  Google Scholar 

  9. Biemond JE, Hannink G, Verdonschot N, Buma P. The effect of E-beam engineerder surface structures on attachment, proliferation and differentiation of human mesenchymal stem cells. Biomed Mater Eng. 2011;21(5–6):271–9.

    CAS  Google Scholar 

  10. Biemond JE, Eufrasio TS, Hannink G, Verdonschot N, Buma P. Assessment of bone ingrowth potential of biomimetic hydroxyapatite and brushite coated porous E-beam structures. J Mater Sci Mater Med. 2011;22(4):917.

    Article  CAS  Google Scholar 

  11. Warnke PH, Douglas T, Wollny P, Sherry E, Steiner M, Galonska S, Becker ST, Springer IN, Wiltfang J, Sivananthan S. Rapid prototyping: porous titanium alloy scaffolds produced by selective laser melting for bone tissue engineering. Tissue Eng Part C Methods. 2009;15(2):115.

    Article  CAS  Google Scholar 

  12. Pattanayak DK, Fukuda A, Matsushita T, Takemoto M, Fujibayashi S, Sasaki K, Nishida N, Nakamura T, Kokubo T. Bioactive Ti metal analogous to human cancellous bone: fabrication by selective laser melting and chemical treatments. Acta Biomater. 2011;7(3):1398.

    Article  CAS  Google Scholar 

  13. Habibovic P, Barrère F, van Blitterswijk CA, de Groot K, Layrolle P. Biomimetic hydroxyapatite coating on metal implants. J Am Ceram Soc. 2002;85(3):517.

    Article  CAS  Google Scholar 

  14. Heinl P, Rottmair A, Körner C, Singer R. Cellular titanium by selective electron beam melting. Adv Eng Mater. 2007;9(5):360.

    Article  CAS  Google Scholar 

  15. Heinl P, Muller L, Korner C, Singer RF, Muller FA. Cellular Ti-6Al-4V structures with interconnected macro porosity for bone implants fabricated by selective electron beam melting. Acta Biomater. 2008;4(5):1536.

    Article  CAS  Google Scholar 

  16. Facchini L, Magalini E, Robotti P, Molinari A. Microstructure and mechanical properties of Ti-6Al-4V produced by electron beam melting of pre-alloyed powders. Rapid Prototyp J. 2009;15(3):171.

    Article  Google Scholar 

  17. Facchini L, Magalini E, Robotti P, Molinari A, Hoges S, Wissenbach K. Ductility of a Ti-6Al-4V alloy produced by selective laser melting of prealloyed powders. Rapid Prototyp J. 2010;16(6):450.

    Article  Google Scholar 

  18. Mullen L, Stamp RC, Fox P, Jones E, Ngo C, Sutcliffe CJ. Selective laser melting: a unit cell approach for the manufacture of porous, titanium, bone in-growth constructs, suitable for orthopedic applications. II. Randomized structures. J Biomed Mater Res B Appl Biomater. 2010;92(1):178.

    Google Scholar 

  19. Redepenning J, Schlessinger T, Burnham S, Lippiello L, Miyano J. Characterization of electrolytically prepared brushite and hydroxyapatite coatings on orthopedic alloys. J Biomed Mater Res. 1996;30(3):287.

    Article  CAS  Google Scholar 

  20. Schouten C, Meijer GJ, van den Beucken JJ, Spauwen PH, Jansen JA. A novel implantation model for evaluation of bone healing response to dental implants: the goat iliac crest. Clin Oral Implants Res. 2010;21(4):414.

    Article  CAS  Google Scholar 

  21. Dhert WJ, Verheyen CC, Braak LH, de Wijn JR, Klein CP, de Groot K, Rozing PM. A finite element analysis of the push-out test: influence of test conditions. J Biomed Mater Res. 1992;26(1):119.

    Article  CAS  Google Scholar 

  22. Levine BR, Sporer S, Poggie RA, Della Valle CJ, Jacobs JJ. Experimental and clinical performance of porous tantalum in orthopedic surgery. Biomaterials. 2006;27(27):4671.

    Article  CAS  Google Scholar 

  23. Sembrano JN, Cheng EY. Acetabular cage survival and analysis of factors related to failure. Clin Orthop Relat Res. 2008;466(7):1657.

    Article  Google Scholar 

  24. Unger AS, Lewis RJ, Gruen T. Evaluation of a porous tantalum uncemented acetabular cup in revision total hip arthroplasty: clinical and radiological results of 60 hips. J Arthroplasty. 2005;20(8):1002.

    Article  Google Scholar 

  25. Barrere F, van der Valk CM, Meijer G, Dalmeijer RA, de Groot K, Layrolle P. Osteointegration of biomimetic apatite coating applied onto dense and porous metal implants in femurs of goats. J Biomed Mater Res B Appl Biomater. 2003;67(1):655.

    Article  CAS  Google Scholar 

  26. Tsukeoka T, Suzuki M, Ohtsuki C, Tsuneizumi Y, Miyagi J, Sugino A, Inoue T, Michihiro R, Moriya H. Enhanced fixation of implants by bone ingrowth to titanium fiber mesh: effect of incorporation of hydroxyapatite powder. J Biomed Mater Res B Appl Biomater. 2005;75(1):168.

    Google Scholar 

  27. Yang GL, He FM, Hu JA, Wang XX, Zhao SF. Biomechanical comparison of biomimetically and electrochemically deposited hydroxyapatite-coated porous titanium implants. J Oral Maxillofac Surg. 2010;68(2):420.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Orthopaedic Research Laboratory, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500HB, Nijmegen, The Netherlands

    J. E. Biemond, G. Hannink, N. Verdonschot & P. Buma

  2. Department of Operating Rooms, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500HB, Nijmegen, The Netherlands

    G. Hannink

  3. Laboratory for Biomechanical Engineering, University of Twente, Enschede, The Netherlands

    N. Verdonschot

Authors
  1. J. E. Biemond
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G. Hannink
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. N. Verdonschot
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. P. Buma
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to J. E. Biemond.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Biemond, J.E., Hannink, G., Verdonschot, N. et al. Bone ingrowth potential of electron beam and selective laser melting produced trabecular-like implant surfaces with and without a biomimetic coating. J Mater Sci: Mater Med 24, 745–753 (2013). https://doi.org/10.1007/s10856-012-4836-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10856-012-4836-7

Keywords

Search

Navigation