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Cress seed mucilage based buccal mucoadhesive gel of venlafaxine: in vivo, in vitro evaluation

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Abstract

Venlafaxine is a newer antipsychotic drug which shows first pass effect. Cress seed is also called as garden cress or green salad. This study examined the mechanical (gel strength, adhesiveness) and rheological properties of cress seed mucilage based gels that contain different ratios of carbopol 934 P (0.5–1.5%). In addition, diffusion of venlafaxine from gel formulations was evaluated. The selected formulation was further analyzed for pharmacokinetic parameters in rabbits. All formulations exhibited pseudoplastic flow with thixotropy. Formulation F5 showed the Cmax of 24.19 ± 0.72 ng/ml by buccal route of administration and 17.98 ± 1.15 ng/ml by oral route of administration. The bioavailability of F5 by buccal route was 54.44% and that of by oral route was 39.60%. A combination of the cress seed mucilage and carbopol 934 P resulted in a prolonged and higher venlafaxine delivery by buccal route of administration.

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Acknowledgments

Authors are grateful to Management and Principal (R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur) for providing necessary facilities to carry out this work.

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Authors and Affiliations

  1. Department of Pharmaceutics, R.C. Patel Institute of Pharmaceutical Education & Research, Karwand Naka, Dist-Dhule, Shirpur, 425 405, Maharashtra, India

    Pankaj Padmakar Nerkar

  2. S. R. T. M. University, Vishnupuri, Nanded, Maharashtra, India

    Surendra Ganeshlal Gattani

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  1. Pankaj Padmakar Nerkar
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  2. Surendra Ganeshlal Gattani
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Correspondence to Surendra Ganeshlal Gattani.

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Nerkar, P.P., Gattani, S.G. Cress seed mucilage based buccal mucoadhesive gel of venlafaxine: in vivo, in vitro evaluation. J Mater Sci: Mater Med 23, 771–779 (2012). https://doi.org/10.1007/s10856-011-4529-7

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  • DOI: https://doi.org/10.1007/s10856-011-4529-7

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