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Development of nanocomposite based on hydroxyethylmethacrylate and functionalized fumed silica: mechanical, chemico–physical and biological characterization

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Abstract

In this research work organic/inorganic nano composites were synthesized from poly-2-hydroxyethylmethacrylate and properly modified silica nanoparticles by in situ polymerization. In particular, fumed nanosilica was functionalized with methacryloylpropyltrimetoxy silane (MPTMS) in order to obtain a more homogeneous, reliable and mechanically performing nano composite. For comparison, nano composites with non functionalised silica were also prepared. Scanning electron microscopy was performed in order to visualize the effects of functionalization on the mode and state of dispersion. This analysis demonstrated that MPTMS grafted onto silica surface acts as an effective coupling agent and assures a good dispersion and distribution of nanoparticles as well as a strong nano particle/matrix interfacial adhesion. As a result of strong interactions occurring between phases, a pronounced increase of the glass transition temperature and mechanical parameters were recorded. Finally, these novel nano composites were seeded with murine fibroblast and human mesenchymal stem cells, and observed in time-lapse experiments proving an effective biological response.

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Acknowledgment

We gratefully thank Prof. Adriana Oliva for the gift of aliquots of mesenchymal stem cells.

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Authors and Affiliations

  1. Section of Biotechnology and Molecular Biology, Department of Experimental Medicine, Faculty of Medicine, Second University of Naples, 80138, Naples, Italy

    Antonella D’Agostino, Mario De Rosa & Chiara Schiraldi

  2. Institute on Polymer Chemistry and Technology, CNR, Via Campi Flegrei 34, 80078, Pozzuoli, NA, Italy

    Maria Emanuela Errico, Mario Malinconico & Maurizio Avella

Authors
  1. Antonella D’Agostino
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  2. Maria Emanuela Errico
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  3. Mario Malinconico
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  4. Mario De Rosa
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  5. Maurizio Avella
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  6. Chiara Schiraldi
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Correspondence to Maria Emanuela Errico or Chiara Schiraldi.

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D’Agostino, A., Errico, M.E., Malinconico, M. et al. Development of nanocomposite based on hydroxyethylmethacrylate and functionalized fumed silica: mechanical, chemico–physical and biological characterization. J Mater Sci: Mater Med 22, 481–490 (2011). https://doi.org/10.1007/s10856-010-4223-1

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  • DOI: https://doi.org/10.1007/s10856-010-4223-1

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