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The bioactivity and ion release of titanium-containing glass polyalkenoate cements for medical applications

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Abstract

The ion release profiles and bioactivity of a series of Ti containing glass polyalkenoate cements. Characterization revealed each material to be amorphous with a T g in the region of 650–660°C. The network connectivity decreased (1.83–1.35) with the addition of TiO2 which was also evident with analysis by X-ray photoelectron spectroscopy. Ion release from cements were determined using atomic absorption spectroscopy for zinc (Zn2+), calcium (Ca2+), strontium (Sr2+), Silica (Si4+) and titanium (Ti4+). Ions such as Zn2+ (0.1–2.0 mg/l), Ca2+ (2.0–8.3 mg/l,) Sr2+ (0.1–3.9 mg/l), and Si4+ (14–90 mg/l) were tested over 1–30 days. No Ti4+ release was detected. Simulated body fluid revealed a CaP surface layer on each cement while cell culture testing of cement liquid extracts with TW-Z (5 mol% TiO2) produced the highest cell viability (161%) after 30 days. Direct contact testing of discs resulted in a decrease in cell viability of the each cement tested.

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Authors and Affiliations

  1. Inamori School of Engineering, Alfred University, Alfred, NY, 14802, USA

    A. W. Wren & M. R. Towler

  2. Materials and Surface Science Institute, University of Limerick, Limerick, Ireland

    N. M. Cummins & F. R. Laffir

  3. Waterford Institute of Technology, Waterford, Ireland

    S. P. Hudson

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  1. A. W. Wren
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  2. N. M. Cummins
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  3. F. R. Laffir
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  4. S. P. Hudson
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  5. M. R. Towler
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Correspondence to A. W. Wren.

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Wren, A.W., Cummins, N.M., Laffir, F.R. et al. The bioactivity and ion release of titanium-containing glass polyalkenoate cements for medical applications. J Mater Sci: Mater Med 22, 19–28 (2011). https://doi.org/10.1007/s10856-010-4184-4

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  • DOI: https://doi.org/10.1007/s10856-010-4184-4

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