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In vitro and in vivo behavior of ketoprofen intercalated into layered double hydroxides

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Abstract

Ketoprofen (Ket) was intercalated into layered double hydroxides (ZnAlLDH and MgAlLDH) using the ionic exchange method. The drug intercalation was confirmed by X-ray diffraction (XRD) and FTIR spectroscopy. Ket release from the inorganic matrix was studied at pH 7.4 in continuous regime with a flow rate of 0.5 and respectively 1.0 ml/min. The kinetical data were interpreted using the Ritger and Peppas model. The data prove that the release kinetics and mechanism depend on the eluent flow rate. Quantification of gastric tolerance shows that the ulcerogenic effect of the intercalated drug is lower than the one of the raw Ket. The antinociceptive effect of both formulations was studied by the hot-plate method performed on mice. The MgAlLDH_Ket formulation shows a tendency towards a stronger antinociceptive effect than its ZnAlLDH_Ket counterpart during the 210 min recorded period.

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Acknowledgments

This research was financially supported by the European Social Fund—„Cristofor I. Simionescu“ Postdoctoral Fellowship Programme (ID POSDRU/89/1.5/S/55216), Sectoral Operational Programme Human Resources Development 2007–2013.

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Authors and Affiliations

  1. Petru Poni Institute of Macromolecular Chemistry Iasi, Aleea Grigore Ghica Voda 41A, 700487, Iasi, Romania

    Mihaela Silion

  2. Faculty of Chemical Engineering and Environmental Protection, Technical University Gh. Asachi, D. Mangeron Boulevard, 700050, Iasi, Romania

    Doina Hritcu & Ionel Marcel Popa

  3. Center for the Study and Therapy of Pain, Gr. T. Popa University of Medicine and Pharmacy Iasi, Strada Universitatii 16, 700115, Iasi, Romania

    Irina M. Jaba, Bogdan Tamba, Dunarea Ionescu & Ostin C. Mungiu

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  1. Mihaela Silion
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Correspondence to Ionel Marcel Popa.

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Silion, M., Hritcu, D., Jaba, I.M. et al. In vitro and in vivo behavior of ketoprofen intercalated into layered double hydroxides. J Mater Sci: Mater Med 21, 3009–3018 (2010). https://doi.org/10.1007/s10856-010-4151-0

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  • DOI: https://doi.org/10.1007/s10856-010-4151-0

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