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Novel self-assembled amphiphilic poly(ε-caprolactone)-grafted-poly(vinyl alcohol) nanoparticles: hydrophobic and hydrophilic drugs carrier nanoparticles

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Abstract

In the present study, we have aimed to produce nanoparticles (NPs) possessing the capability of carrying both of the hydrophobic and hydrophilic drugs and reveal significant release for both drug types. Poly(ε-caprolactone) (PCL) grafted poly(vinyl alcohol) (PVA) copolymer (PCL-g-PVA) has been prepared and shaped in nano-particulate form to be adequate for carrying the drugs. Stannous octoate (Sn(II)Oct2) was used to catalyze PVA and ε-caprolactone monomer to chemically bond. Moreover, this catalyst enhanced side chain polymerization reaction for the utilized ε-caprolactone monomer to form poly(ε-caprolactone) (PCL). The formed PCL was attached as branches with PVA backbone. 1H NMR has confirmed formation of PCL and grafting of PVA by this new polymer. Moreover, the vibration modes in the functional groups of PCL-g-PVA have been detected by FT-IR. The thermal alteration in the grafted polymer was checked by TGA analysis. The successfully synthesized grafted copolymer was able to self-aggregate into NPs by direct dialysis method. The size, morphology and charges associated with the obtained NPs were analyzed by DLS, TEM and ELS, respectively. PCL-g-PVA NPs were investigated as drug carrier models for hydrophobic and hydrophilic anti cancer drugs; paclitaxel and doxorubicin. In vitro drug release experiments were conducted; the loaded NPs reveal continuous and sustained release form for both drugs, up to 20 and 15 days for paclitaxel and doxorubicin, respectively. However, in a case of using pure drugs only, both drugs completely released within 1–2 h. The overall obtained results strongly recommend the use these novel NPs in future drug delivery systems.

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Acknowledgement

This work was supported by Korean Research Foundation Grant founded by Korean Government (MOEHRD) (The Center for Health Care Technology, Chonbuk National University, Jeonju 561–756 Republic of Korea).

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Authors and Affiliations

  1. Department of Bionano System Engineering, Chonbuk National University, Jeonju, 561-756, Republic of Korea

    Faheem A. Sheikh

  2. Chemical Engineering Department, Faculty of Engineering, El-Minia University, El-Minia, Egypt

    Nasser A. M. Barakat

  3. Center for Healthcare Technology Development, Chonbuk National University, Jeonju, 561-756, Republic of Korea

    Nasser A. M. Barakat

  4. Department of Polymer Nano Science and Technology, Chonbuk National University, Jeonju, 561-756, Republic of Korea

    Muzafar A. Kanjwal

  5. Department of Mechanical Engineering, University of Wisconsin, Milwaukee, WI, 53211, USA

    Santosh Aryal

  6. Department of Textile Engineering, Chonbuk National University, Jeonju, 561-756, Republic of Korea

    Myung Seob Khil & Hak-Yong Kim

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  1. Faheem A. Sheikh
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  2. Nasser A. M. Barakat
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  3. Muzafar A. Kanjwal
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  4. Santosh Aryal
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Correspondence to Hak-Yong Kim.

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Sheikh, F.A., Barakat, N.A.M., Kanjwal, M.A. et al. Novel self-assembled amphiphilic poly(ε-caprolactone)-grafted-poly(vinyl alcohol) nanoparticles: hydrophobic and hydrophilic drugs carrier nanoparticles. J Mater Sci: Mater Med 20, 821–831 (2009). https://doi.org/10.1007/s10856-008-3637-5

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  • DOI: https://doi.org/10.1007/s10856-008-3637-5

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