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Development of core-shell microcapsules by a novel supercritical CO2 process

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Abstract

5-fluorouracil-SiO2-poly(L-lactide) (5-Fu-SiO2-PLLA) microcapsules were prepared in a novel process of solution-enhanced dispersion by supercritical CO2 (SEDS). The SiO2 nanoparticles were loaded with 5-Fu by adsorption at the first place, then the 5-Fu-SiO2 nanoparticles were coated with PLLA by a modified SEDS process. The resulted microcapsules were characterized by scanning electron microscope (SEM), laser diffraction particle size analyzer, Fourier transform infrared spectrometer (FTIR) and thermogravimeter-differential scanning calorimeter (TG-DSC). The drug load, encapsulation efficiency and drug release profiles were also determined. The resulted microcapsules exhibited a rather spherical shape, smooth surface, and a narrow particle size distribution with a mean particle size of 536 nm. The drug load and encapsulation efficiency of the samples were 0.18% and 80.53%, respectively, 25.05% of 5-Fu was released in the first half hour, then drug released in a sustained process, which was much slower than that of without coated by PLLA. The results indicated that the modified SEDS process could be used to produce drug-polymer microcapsules with a core-shell structure, high encapsulation efficiency and sustained drug release effect.

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Acknowledgement

We are grateful to the HKRITA for providing funding support to this research through projects ITP/001/07TP and The Hong Kong Polytechnic University through projects BB6K and BB6R.

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  1. Institute of Textiles and Clothing, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China

    Ai-Zheng Chen, Yi Li, Dong Chen & Jun-Yan Hu

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  1. Ai-Zheng Chen
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  2. Yi Li
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  3. Dong Chen
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Correspondence to Yi Li.

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Chen, AZ., Li, Y., Chen, D. et al. Development of core-shell microcapsules by a novel supercritical CO2 process. J Mater Sci: Mater Med 20, 751–758 (2009). https://doi.org/10.1007/s10856-008-3633-9

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  • DOI: https://doi.org/10.1007/s10856-008-3633-9

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