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Degradation and drug release properties of poly-α,β-[N-(2-hydroxyethyl)-l-aspartamide]-g-poly(2,2-dimethyltrimethylene carbonate)

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Abstract

A series of biodegradable amphiphilic graft copolymers with poly-α,β-[N-(2-hydroxyethyl)-l-aspartamide] (PHEA) as the backbone and poly(2,2-dimethyltrimethylene carbonate) (PDTC) segments with different lengths as the grafted branches were synthesized and characterized. The in vitro degradation of the obtained PHEA-g-PDTC copolymers was studied. With particular branch lengths, PHEA-g-PDTC can form self-assembling micelles in an aqueous solution. Transmission electron microscopy (TEM) images demonstrated that the micelles were regularly spherical in shape. The particle size and distribution of the micelles were measured. Nanoparticle drug delivery systems were prepared by the direct dissolution method. The in vitro release behaviors of two drugs, prednisone acetate and tegafur, with different water solubilities were investigated.

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Acknowledgments

The authors thank the National Natural Science Foundation of China for the research grants (20204010 and 20474046). One of the authors, Si-Xue Cheng, is grateful to the Ministry of Education of China for the financial support of “Trans-Century Training Programme Foundation for the Talents”.

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Authors and Affiliations

  1. Key Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan University, Wuhan, 430072, P.R. China

    Tao Peng, Jing Su, Si-Xue Cheng & Ren-Xi Zhuo

Authors
  1. Tao Peng
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  2. Jing Su
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  3. Si-Xue Cheng
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  4. Ren-Xi Zhuo
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Correspondence to Ren-Xi Zhuo.

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Peng, T., Su, J., Cheng, SX. et al. Degradation and drug release properties of poly-α,β-[N-(2-hydroxyethyl)-l-aspartamide]-g-poly(2,2-dimethyltrimethylene carbonate). J Mater Sci: Mater Med 18, 1765–1769 (2007). https://doi.org/10.1007/s10856-007-3022-9

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  • DOI: https://doi.org/10.1007/s10856-007-3022-9

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