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Novel elastic material from collagen for tissue engineering

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Abstract

Elastic collagen gel (e-gel) was prepared from salmon atelocollagen fibrillar gel reinforced by 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide (EDC) mediated cross-linking (f-gel). The preparation consisted of a simple heat treatment of the f-gel at 80 °C, in which the f-gel drastically shrank and the collagen fibril structure was deformed. The e-gel obtained showed rubber-like elasticity; its stress–strain behavior little changed through repeated stretching. The elongation at the breaking point was approximately 230%. Furthermore, normal human osteoblasts showed good attachment and proliferation on the e-gel. These results suggest its potential to be utilized for the development of tissue engineering.

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Acknowledgements

Authors thank Dr. T. Sakurai for his helpful advice on the mechanical tests.

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Authors and Affiliations

  1. Division of Molecular Chemistry, Graduate School of Engineering, Hokkaido University, Kita-13, Nishi-8, Kita-ku, Sapporo, Hokkaido, 060-8628, Japan

    Shunji Yunoki, Nobuhiro Nagai & Masanobu Munekata

  2. Ihara & Company Ltd., 3-263-23 Zenibako, Otaru, Hokkaido, 047-0261, Japan

    Kazuo Mori & Takeshi Suzuki

Authors
  1. Shunji Yunoki
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  2. Kazuo Mori
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  3. Takeshi Suzuki
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  4. Nobuhiro Nagai
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  5. Masanobu Munekata
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Correspondence to Shunji Yunoki.

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Yunoki, S., Mori, K., Suzuki, T. et al. Novel elastic material from collagen for tissue engineering. J Mater Sci: Mater Med 18, 1369–1375 (2007). https://doi.org/10.1007/s10856-007-0121-6

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  • DOI: https://doi.org/10.1007/s10856-007-0121-6

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