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A pH-responsive CaO2@ZIF-67 system endows a scaffold with chemodynamic therapy properties

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Abstract

The insufficient of H2O2 restricts the efficacy of chemodynamic therapy in tumor microenvironment. Calcium peroxide (CaO2) is expected to solve this problem due to its H2O2-evolving ability. However, it prematurely decomposes in the moist air or water before reaching tumor site. In this study, zeolitic imidazolate framework-67 (ZIF-67) was in-situ grown on the surface of CaO2 to construct a pH-responsive CaO2@ZIF-67 system and then incorporated into poly-L-lactic acid (PLLA) to prepare PLLA/CaO2@ZIF-67 scaffold by selective laser sintering technology. On the one hand, ZIF-67 is used as a chemodynamic therapy agent due to the release of cobalt ions after degradation. On the other hand, ZIF-67 can serve as protective layers to prevent premature decomposition of CaO2 due to its hydrophobic properties, and then CaO2 is exposed and reacts with water to form H2O2 after the pH-responsive degradation of ZIF-67 under tumor acidic microenvironment. Results showed that the PLLA/CaO2@ZIF-67 scaffold could sustainedly produce H2O2 under acidic pH and achieve 84.64% antitumor ratio against MG-63 cells. In addition, the scaffold also promoted proliferation and osteogenic differentiation of mouse bone marrow mesenchymal stem cells due to the release of calcium ions. The prepared PLLA/CaO2@ZIF-67 scaffold with chemodynamic antitumor and osteogenic effects has great potential to treat tumorous bone defect.

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Acknowledgements

This study was supported by the following funds: (1) The Natural Science Foundation of China (51935014, 52165043, 52105352, 82072084, 81871498); (2) JiangXi Provincial Natural Science Foundation of China (2020ACB214004, 20202BAB214011); (3) The Provincial Key R & D Projects of Jiangxi (20201BBE51012); (4) The Project of State Key Laboratory of High Performance Complex Manufacturing; (5) High-level Talents Scientific Research Initiation Project of Jiangxi University of Science and Technology (205200100487); and (6) Science and Technology Research Project of Education Department of Jiangxi Province (GJJ200863); (7) The Natural Science Foundation of China (81960880); (8) Guangdong Province Higher Vocational Colleges & Schools Pearl River Scholar Funded Scheme (2018); (9) Technology Innovation Platform Project of Shenzhen Institute of Information Technology 2020 (PT2020E002).

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Authors and Affiliations

  1. Institute of Additive Manufacturing, Jiangxi University of Science and Technology, Nanchang, 330013, China

    Guowen Qian, Junzhe Wang & Cijun Shuai

  2. Ganjiang Innovation Academy, Chinese Academy of Sciences, Ganzhou, 341119, China

    Liuyimei Yang

  3. Department of Orthopedics, The Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang, 330006, China

    Zhikui Zeng

  4. Shenzhen Institute of Information Technology, School of Sino-German Robotics, Shenzhen, 518172, China

    Zhenyu Zhao

  5. The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Xiangya Hospital, Central South University, Changsha, 410078, Hunan, China

    Shuping Peng

  6. NHC Key Laboratory of Carcinogenesis of Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya, School of Medicine, Cancer Research Institute, School of Basic Medical Science, Central South University, Changsha, 410013, Hunan, China

    Shuping Peng

  7. State Key Laboratory of High Performance Complex Manufacturing, Central South University, Changsha, 410083, China

    Cijun Shuai

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  1. Guowen Qian
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Qian, G., Wang, J., Yang, L. et al. A pH-responsive CaO2@ZIF-67 system endows a scaffold with chemodynamic therapy properties. J Mater Sci 58, 1214–1228 (2023). https://doi.org/10.1007/s10853-022-08103-w

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