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Dual antibacterial polypeptide-coated PCL@ZIF-8 nanofiber reduces infection and inflammation in burn wounds

  • Materials for life sciences
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Abstract

Burns on human skin often leads to slow recovery because of continuous wound infections caused by the loss of skin protection. In this study, a seed-free soaking method is put forward to prepare PCL@ZIF-8/εPL nanofibers as a dressing for burn wounds. This ZIF-8-coated polycaprolactone (PCL) fiber exhibits increased specific surface area, significantly increasing the polypeptide loading of epsilon polylysine (εPL) from 12 to 20 wt.%. The antibacterial experiment found that ZIF-8 and εPL exhibited dual antibacterial properties, and after εPL was loaded to ZIF-8, the nanofiber demonstrated stronger antibacterial properties that can better kill the remaining tenacious bacteria. This high-efficiency bactericidal property, combined with the ability to protect wounds from common infections by bacteria in the air, would promote wound healing, shortening the healing time period from 24 to 17 days. Further tissue sections confirm that the shielding effect and dual antibacterial properties of the composite fiber membrane are the reasons behind the acceleration of the healing of burns and scalds. Shielding and antibacterial material are helpful for the treatment of burns and scalds, and it may also guide the treatment of other types of wounds.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (11904193 and 51973100), the National Key Research and Development Project of China (2019YFC0121402), and the State Key Laboratory of Bio-Fibers and Eco-Textiles, Qingdao University (RZ2000003334 and G2RC202022).

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  1. Xiao-Han Bai and Jun Zhang have contributed equally to this work

Authors and Affiliations

  1. Collaborative Innovation Center for Nanomaterials & Devices, College of Physics, Qingdao University, Qingdao, 266071, People’s Republic of China

    Xiao-Han Bai, Jun Zhang, Guo-Ting Cheng, Xiao-Fei Liu, Tian-Cai Sun, Jun Yang, Zhi-Kai Cao & Yun-Ze Long

  2. Department of Mechanical Engineering, Center for Nanofibers & Nanotechnology, National University of Singapore, Singapore, 117574, Singapore

    Seeram Ramakrishna

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  1. Xiao-Han Bai
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Bai, XH., Zhang, J., Cheng, GT. et al. Dual antibacterial polypeptide-coated PCL@ZIF-8 nanofiber reduces infection and inflammation in burn wounds. J Mater Sci 57, 3678–3687 (2022). https://doi.org/10.1007/s10853-021-06832-y

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