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Microstructure, mechanical properties and in vitro biocompatibilities of a novel bionic hydroxyapatite bone scaffold prepared by the addition of boron nitride

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Abstract

Hydroxyapatite (HA) is an ideal bone insert material due to its biocompatibility and osteoconductivity, but the poor mechanical properties limit its wide application in clinical practice. The aim of this work is to fabricate a novel composite that with similar porous structure to cortical bone and high mechanical properties by the addition of boron nitride (BN) and sintered in air at 1250 °C for 40 min. In mechanical properties, the maximum flexural strength, elastic modulus and fracture toughness are 94.04 MPa, 69.46 GPa and 1.16 MPa m1/2, respectively, which are improved by 20.56%, 12.87% and 8.41%, respectively. In the microscopy of surface and fracture surface, the porous structure similar to cortical bone is observed. There are microscale and nanoscale pores, and the pores present an interconnected structure. In vitro biocompatibility assessment, the addition of BN and its reaction product have no adverse effect on osteoblast viability, which even promotes osteogenic differentiation and mineralization.

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Acknowledgements

This work was supported by the National Key R&D Program of China (2017YFC1103800), the State Key Laboratory of Advanced Technology for Materials Synthesis and Processing (Wuhan University of Technology) (2018-KF-2), and the Fundamental Research Funds for the Central Universities (WUT: 2018III006CG, WUT: 195201028).

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Authors and Affiliations

  1. State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan, 430070, China

    Changbo Wang, Jian Zhou, Xiaoguang Huang & Guizhen Liu

  2. State Key Laboratory of Silicate Materials for Architectures, Wuhan University of Technology, Wuhan, 430070, China

    Jinyang Feng

  3. Hubei Key Laboratory of Broadband Wireless Communication and Sensor Networks, Wuhan University of Technology, Wuhan, 430070, China

    Lin Wang

  4. Materials Research Institute, The Pennsylvania State University, University Park, PA, 16801, USA

    Jiping Cheng

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  1. Changbo Wang
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  3. Jian Zhou
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Correspondence to Jian Zhou.

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Wang, C., Feng, J., Zhou, J. et al. Microstructure, mechanical properties and in vitro biocompatibilities of a novel bionic hydroxyapatite bone scaffold prepared by the addition of boron nitride. J Mater Sci 55, 14501–14515 (2020). https://doi.org/10.1007/s10853-020-05015-5

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