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Self-healing alginate hydrogel based on dynamic acylhydrazone and multiple hydrogen bonds

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Abstract

Dialdehyde-terminated PEG (PEG–CHO) and adipic dihydrazide-modified alginate (ALG-ADH) was developed to provide aldehyde and hydrazide active sites, respectively, and thus to obtain dynamic acylhydrazone bonds, which endow alginate hydrogel with excellent self-healing property. Different concentrations of cross-linking agent have been added, and their influence on the structure, morphology, mechanical properties and self-healing performance has been evaluated. The gelation kinetics, shear performance and compressive property have been investigated in detail. The hydrogel with 5% cross-linking agent exhibited the highest mechanical performance, with the shear modulus of 0.234 MPa and compressive modulus of 0.288 MPa. Due to dynamic acylhydrazone and multiple hydrogen bonds, the hydrogels have demonstrated excellent self-healing properties. After self-healing process, the hydrogel has retained 84.4% of the original tensile modulus. The as-prepared alginate hydrogel was molded into different shapes to exhibit the excellent plasticity. Moreover, when tetracycline hydrochloride was loaded into the hydrogel system as a model drug, the modified alginate hydrogel demonstrated the fastest drug release rate at pH = 7.4. It is suggested that the self-healing alginate hydrogel has a great potential in drug delivery, such as targeted drug release in intestinal treatment.

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Acknowledgements

The authors gratefully acknowledge financial support from National Natural Science Foundation of China (No. 51503025), Liaoning Natural Science Foundation of China (No. 20170540175), the Fundamental Research Funds for the Central Universities (DUT16LK14) and China Postdoctoral Science Foundation (No. 2016M591426).

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Authors and Affiliations

  1. State Key Laboratory of Fine Chemicals, Dalian University of Technology, 116024, Dalian, People’s Republic of China

    Chengde Liu, Cheng Liu, Jinyan Wang & Xigao Jian

  2. Department of Polymer Science and Engineering, Dalian University of Technology, 116024, Dalian, People’s Republic of China

    Liyuan Qiao, Chengde Liu, Cheng Liu, Liquan Yang, Wentao Liu, Jinyan Wang & Xigao Jian

  3. Liaoning Province Engineering Research Centre of High Performance Resins, 116024, Dalian, People’s Republic of China

    Chengde Liu, Cheng Liu, Jinyan Wang & Xigao Jian

  4. College of Environmental Science and Technology, Dalian Maritime University, 116026, Dalian, People’s Republic of China

    Manxia Zhang

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  1. Liyuan Qiao
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Correspondence to Cheng Liu.

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Qiao, L., Liu, C., Liu, C. et al. Self-healing alginate hydrogel based on dynamic acylhydrazone and multiple hydrogen bonds. J Mater Sci 54, 8814–8828 (2019). https://doi.org/10.1007/s10853-019-03483-y

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