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Synthesis of polyphosphazene and preparation of microspheres from polyphosphazene blends with PMMA for drug combination therapy

  • Materials for life sciences
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Abstract

Drug combination therapy is an emerging technology to treat the diseases which are still annoyance to human being. Combination of two or more drugs can deal with diseases in a better way. Various different techniques have been introduced which can deliver combination of drugs in a safe and more controlled manner. In our research, we prepared polyphosphazene-based blend microspheres which can deliver two different drugs in a much sustained manner for long time. “Acetamidophenol,” commonly used drug, was attached to the polyphosphazene main chain to produce drug–polymer conjugates, and these were then blended with PMMA in different ratios to fabricate the microspheres of variable and controlled size. Another anticancer drug “camptothecin” was loaded in these microspheres to fabricate dual-drug-loaded microsphere. Furthermore, in vitro drug release behaviors of fabricated microspheres were also demonstrated.

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Authors and Affiliations

  1. State Key Laboratory of Chemical Engineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, 310027, People’s Republic of China

    Raja Summe Ullah, Li Wang, Haojie Yu, Muhammad Haroon, Tarig Elshaarani, Kaleem-ur-Rahman Naveed, Shah Fahad, Amin Khan, Ahsan Nazir & Xia Xia

  2. Oncological Surgery and Cancer Center, The First Affiliated Hospital, Zhejiang University, Hangzhou, 310003, People’s Republic of China

    Lisong Teng

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  1. Raja Summe Ullah
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  2. Li Wang
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  3. Haojie Yu
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  4. Muhammad Haroon
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  5. Tarig Elshaarani
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  6. Kaleem-ur-Rahman Naveed
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  7. Shah Fahad
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  8. Amin Khan
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  10. Xia Xia
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  11. Lisong Teng
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Correspondence to Li Wang or Haojie Yu.

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Ullah, R.S., Wang, L., Yu, H. et al. Synthesis of polyphosphazene and preparation of microspheres from polyphosphazene blends with PMMA for drug combination therapy. J Mater Sci 54, 745–764 (2019). https://doi.org/10.1007/s10853-018-2843-x

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