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Targeted delivery and thermo/pH-controlled release of doxorubicin by novel nanocapsules

  • Biomaterials
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Abstract

The ideal drug delivery system (DDS) should be able to deliver a therapeutic dose of drug to the target site in the body and maintain appropriate concentration over a desired period of time. Thermo/pH-responsive targeted polymeric nanocapsules (p(NIPA-co-AAc-co-GAA)) for delivery of anticancer drug (doxorubicin, DOX) were fabricated by W/O/W double emulsion solvent evaporation technique. The morphology, hydrodynamic diameter, size distribution, thermo/pH responsiveness, targeted property, anti-tumor efficacy, encapsulation efficiency, drug loading and controlled release of drug were systematically investigated. The results demonstrated that p(NIPA-co-AAc-co-GAA) nanocapsules minimized the drug leakage and reduced the toxic and side effects on normal tissues, while triggered and accelerated the release of drug in tumor tissues. It is very interesting for the site-specific release of drug to improve curative effects and reduce side effects, implying that p(NIPA-co-AAc-co-GAA) nanocapsule is a attractive candidate for DDS.

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Acknowledgements

This work was supported by Natural Science Foundation of Tianjin (Nos. 16JCYBJC23800, 16JCZDJC37500) and Training Program of Innovation and Entrepreneurship for Undergraduates (201610058064).

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Authors and Affiliations

  1. State Key Laboratory of Separation Membranes and Membrane Processes, Tianjin Engineering Center for Safety Evaluation of Water Quality and Safeguards Technology, School of Environment and Chemical Engineering, Tianjin Polytechnic University, Tianjin, 300387, China

    Xiaoling He, Fang Liang, Fu Wang, Liangshuai Zou, Jing Wang, Chaokai Tang & Kongyin Zhao

  2. College of Life Science, Nankai University, Tianjin, 300071, China

    Dongsheng Wei

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  1. Xiaoling He
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  2. Fang Liang
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  3. Fu Wang
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  4. Liangshuai Zou
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  5. Jing Wang
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  6. Chaokai Tang
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  7. Kongyin Zhao
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Correspondence to Xiaoling He or Dongsheng Wei.

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He, X., Liang, F., Wang, F. et al. Targeted delivery and thermo/pH-controlled release of doxorubicin by novel nanocapsules. J Mater Sci 53, 2326–2336 (2018). https://doi.org/10.1007/s10853-017-1679-0

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  • DOI: https://doi.org/10.1007/s10853-017-1679-0

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