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Immunostimulating peptide interfacial imprinted magnetic microspheres synthesized via Pickering emulsion polymerization

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Abstract

In this work, super-paramagnetic interface molecularly imprinted microspheres (MIMIMs) were prepared using an immunostimulating hexapeptide as template via photo-initiated Pickering emulsion polymerization by the self-assembly of the template-immobilized silica nanoparticles at the oil–water interface under room temperature. The whole experiment process was tracked and analyzed by various characterization methods. Results manifest that the obtained MIMIMs showed excellent recognition property and rapid-efficiency separation for template peptide due to their accessible imprinted sites and desired magnetic susceptibility. Moreover, MIMIMs were used in competitive rebinding and reusability tests, which demonstrated their potential application in the enrichment of IHH and sustainable performance in resource-saving.

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Acknowledgements

The authors are grateful for the financial support provided by the National Natural Science Foundation of China (Grant No. 51433008), and the Graduate Starting Seed Fund of Northwestern Polytechnical University (Grant No. Z2016034).

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Authors and Affiliations

  1. Department of Applied Chemistry, Key Laboratory of Space Applied Physics and Chemistry of Ministry of Education, School of Science, Northwestern Polytechnical University, Xi’an, 710072, People’s Republic of China

    Xiaoyan Zhang, Xiaoling Hu, Ping Guan, Nan Zhang, Ji Li & Chunbao Du

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  1. Xiaoyan Zhang
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  2. Xiaoling Hu
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  3. Ping Guan
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  4. Nan Zhang
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  5. Ji Li
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Correspondence to Xiaoyan Zhang.

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Zhang, X., Hu, X., Guan, P. et al. Immunostimulating peptide interfacial imprinted magnetic microspheres synthesized via Pickering emulsion polymerization. J Mater Sci 52, 4713–4726 (2017). https://doi.org/10.1007/s10853-016-0714-x

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