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Streptomycin-modified Fe3O4–Au@Ag core–satellite magnetic nanoparticles as an effective antibacterial agent

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Abstract

The fabrication of ideal Ag-modified magnetic nanoparticles (MNPs) as a recyclable antibacterial agent that possesses good dispersibility, strong magnetic responsiveness, and high bactericidal activity is still a challenge. In this study, we described a simple polyethyleneimine (PEI)-assisted connection method for fabricating high-performance Au@Ag-loaded MNPs (Fe3O4–Au@Ag). The Fe3O4 cores are first modified with uniform PEI shell (2 nm) through self-assembly under sonication. And then, the negatively charged Au@Ag NPs with a uniform size of 5 nm are adsorbed on the surface of the Fe3O4 cores through electrostatic interaction. The Au@Ag-loaded MNPs were obtained within 30 min, and they were highly uniform in size and shape with good dispersibility and strong magnetic responsivity. With the aid of the magnetic core, the residual nanoparticles can be recycled from solution through an external magnetic field. These dense Au@Ag NPs acted as antibacterial satellites in highly active areas for Ag ion releasing and bacteria contacting. The Fe3O4–Au@AgMNPs exhibited good antibacterial activity against both Gram-negative and Gram-positive bacteria. Moreover, the antibacterial activity of Fe3O4–Au@AgMNPs was significantly improved by streptomycin antibiotic modification. Enhancement of the bactericidal efficiency of Fe3O4–Au@Ag-streptomycin revealed the presence of a synergistic effect between the MNPs and the introduced antibiotic.

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References

  1. Hajipour MJ, Fromm KM, Ashkarran AA, Jimenez de Aberasturi D, de Larramendi IR, Rojo T, Serpooshan V, Parak WJ, Mahmoudi M (2012) Antibacterial properties of nanoparticles. Trends Biotechnol 30:499–511

    Article  Google Scholar 

  2. Ray PC, Khan SA, Singh AK, Senapati D, Fan Z (2012) Nanomaterials for targeted detection and photothermal killing of bacteria. Chem Soc Rev 41:3193–3209

    Article  Google Scholar 

  3. Zheng Y, Xiao M, Jiang S, Ding F, Wang J (2013) Coating fabrics with gold nanorods for colouring, UV-protection, and antibacterial functions. Nanoscale 5:788–795

    Article  Google Scholar 

  4. Singh MP, Raghupathy Y, Natarajan KA, Srivastava C (2015) Synthesis, electron microscopy and anti-microbial properties of Fe3O4–Ag nanotubes. RSC Adv 5:38164–38169

    Article  Google Scholar 

  5. Chang Y-N, Ou X-M, Zeng G-M, Gong J-L, Deng C-H, Jiang Y, Liang J, Yuan G-Q, Liu H-Y, He X (2015) Synthesis of magnetic graphene oxide–TiO2 and their antibacterial properties under solar irradiation. Appl Surf Sci 343:1–10

    Article  Google Scholar 

  6. Singh S, Barick KC, Bahadur D (2015) Inactivation of bacterial pathogens under magnetic hyperthermia using Fe3O4–ZnO nanocomposite. Powder Technol 269:513–519

    Article  Google Scholar 

  7. Moosavi R, Ramanathan S, Lee YY, Siew Ling KC, Afkhami A, Archunan G, Padmanabhan P, Gulyás B, Kakran M, Selvan ST (2015) Synthesis of antibacterial and magnetic nanocomposites by decorating graphene oxide surface with metal nanoparticles. RSC Adv 5:76442–76450

    Article  Google Scholar 

  8. Chudasama B, Vala AK, Andhariya N, Upadhyay RV, Mehta RV (2010) Enhanced antibacterial activity of bifunctional Fe3O4-Ag core-shell nanostructures. Nano Res 2:955–965

    Article  Google Scholar 

  9. Lin L, Cui H, Zeng G, Chen M, Zhang H, Xu M, Shen X, Bortolini C, Dong M (2013) Ag–CuFe2O4 magnetic hollow fibers for recyclable antibacterial materials. J Mater Chem B 1:2719–2723

    Article  Google Scholar 

  10. Xiong R, Lu C, Wang Y, Zhou Z, Zhang X (2013) Nanofibrillated cellulose as the support and reductant for the facile synthesis of Fe3O4/Ag nanocomposites with catalytic and antibacterial activity. J Mater Chem A 1:14910–14918

    Article  Google Scholar 

  11. Jeong CJ, Sharker SM, In I, Park SY (2015) Iron Oxide@PEDOT-Based Recyclable Photothermal Nanoparticles with Poly(vinylpyrrolidone) Sulfobetaines for Rapid and Effective Antibacterial Activity. ACS Appl Mater Interfaces 7:9469–9478

    Article  Google Scholar 

  12. Chen X, Yuan F, Zhang H, Huang Y, Yang J, Sun D (2016) Recent approaches and future prospects of bacterial cellulose-based electroconductive materials. J Mater Sci 51:5573–5588. doi:10.1007/s10853-016-9899-2

    Article  Google Scholar 

  13. Maleki A, Movahed H, Paydar R (2016) Design and development of a novel cellulose/γ-Fe2O3/Ag nanocomposite: a potential green catalyst and antibacterial agent. RSC Adv 6:13657–13665

    Article  Google Scholar 

  14. Gong P, Li H, He X, Wang K, Hu J, Tan W, Zhang S, Yang X (2007) Preparation and antibacterial activity of Fe3O4@Ag nanoparticles. Nanotechnology 18:285604

    Article  Google Scholar 

  15. Ríos A, Zougagh M, Bouri M (2013) Magnetic (nano)materials as an useful tool for sample preparation in analytical methods. A Rev Anal Methods 5:4558

    Article  Google Scholar 

  16. Chen SS, Xu H, Xu HJ, Yu GJ, Gong XL, Fang QL, Leung KC, Xuan SH, Xiong QR (2015) A facile ultrasonication assisted method for Fe3O4@SiO2-Ag nanospheres with excellent antibacterial activity. Dalton Trans 44:9140–9148

    Article  Google Scholar 

  17. Singh S, Bahadur D (2015) Catalytic and antibacterial activity of Ag decorated magnetic core shell nanosphere. Colloids Surf B 133:58–65

    Article  Google Scholar 

  18. Zhang C, Wang X, Sun J, Kou T, Zhang Z (2013) Synthesis and antibacterial properties of magnetically recyclable nanoporous silver/Fe3O4 nanocomposites through one-step dealloying. Cryst Eng Comm 15:3965

    Article  Google Scholar 

  19. Amarjargal A, Tijing LD, Im I-T, Kim CS (2013) Simultaneous preparation of Ag/Fe3O4 core–shell nanocomposites with enhanced magnetic moment and strong antibacterial and catalytic properties. Chem Eng J 226:243–254

    Article  Google Scholar 

  20. Zhang X, Niu H, Yan J, Cai Y (2011) Immobilizing silver nanoparticles onto the surface of magnetic silica composite to prepare magnetic disinfectant with enhanced stability and antibacterial activity. Colloids Surf, A 375:186–192

    Article  Google Scholar 

  21. Wang C, Xu J, Wang J, Rong Z, Li P, Xiao R, Wang S (2015) Polyethylenimine-interlayered silver-shell magnetic-core microspheres as multifunctional SERS substrates. J. Mater Chem C 3:8684–8693

    Article  Google Scholar 

  22. Wang C, Li P, Wang J, Rong Z, Pang Y, Xu J, Dong P, Xiao R, Wang S (2015) Polyethylenimine-interlayered core-shell-satellite 3D magnetic microspheres as versatile SERS substrates. Nanoscale 7:18694–18707

    Article  Google Scholar 

  23. Xuan S, Wang F, Wang Y-XJ, Yu JC, Leung KC-F (2010) Facile synthesis of size-controllable monodispersed ferrite nanospheres. J Mater Chem 20:5086

    Article  Google Scholar 

  24. Ko F-H, Chang Y-C (2014) Aptamer based surface enhanced Raman scattering detection of adenosine using various core sizes of Au–Ag core–shell nanoparticles. RSC, Adv 4:26251

    Article  Google Scholar 

  25. Fang Y, Guo S, Zhu C, Zhai Y, Wang E (2010) Self-Assembly of cationic polyelectrolyte-functionalized graphene nanosheets and gold nanoparticles: a two-dimensional heterostructure for hydrogen peroxide sensing. langmuir 26:11277–11282

    Article  Google Scholar 

  26. Deng H, Li X, Peng Q, Wang X, Chen J, Li Y (2005) Monodisperse magnetic single-crystal ferrite microspheres. Angew Chem 117:2842–2845

    Article  Google Scholar 

  27. An Q, Zhang P, Li JM, Ma WF, Guo J, Hu J, Wang CC (2012) Silver-coated magnetite-carbon core-shell microspheres as substrate-enhanced SERS probes for detection of trace persistent organic pollutants. Nanoscale 4:5210–5216

    Article  Google Scholar 

  28. An Q, Yu M, Zhang Y, Ma W, Guo J, Wang C (2012) Fe3O4@Carbon microsphere supported Ag–Au bimetallic nanocrystals with the enhanced catalytic activity and selectivity for the reduction of nitroaromatic compounds. J Phys Chem C 116:22432–22440

    Article  Google Scholar 

  29. Shen A, Chen L, Xie W, Hu J, Zeng A, Richards R, Hu J (2010) Triplex Au-Ag-C core-shell nanoparticles as a novel raman label. Adv Funct Mater 20:969–975

    Article  Google Scholar 

  30. Pei L, Ou Y, Yu W, Fan Y, Huang Y, Lai K (2015) Au–Ag core-shell nanospheres for surface-enhanced raman scattering detection of sudan i and sudan ii in chili powder. J Nanomater 2015:1–8

    Google Scholar 

  31. Lou L, Yu K, Zhang Z, Huang R, Zhu J, Wang Y, Zhu Z (2012) Dual-mode protein detection based on Fe3O4–Au hybrid nanoparticles. Nano Res 5:272–282

    Article  Google Scholar 

  32. Lou L, Yu K, Zhang Z, Li B, Zhu J, Wang Y, Huang R, Zhu Z (2011) Functionalized magnetic-fluorescent hybrid nanoparticles for cell labelling. Nanoscale 3:2315–2323

    Article  Google Scholar 

  33. Nie C, Cheng C, Peng Z, Ma L, He C, Xia Y, Zhao C (2016) Mussel-inspired coatings on Ag nanoparticle-conjugated carbon nanotubes: bactericidal activity and mammal cell toxicity. J Mater Chem B 4:2749–2756

    Article  Google Scholar 

  34. Cong Y, Xia T, Zou M, Li Z, Peng B, Guo D, Deng Z (2014) Mussel-inspired polydopamine coating as a versatile platform for synthesizing polystyrene/Ag nanocomposite particles with enhanced antibacterial activities. J Mater Chem B 2:3450–3461

    Article  Google Scholar 

  35. Dey J, Biswas K, Thapa U, Joshi S, Kharbangar IS, Sultana N, Ismail K (2015) Facile synthesis of silver nanoparticles and their synergistic antibacterial activity in combination with commercial antibiotics. Bull Chem Soc Jpn 88:352–357

    Article  Google Scholar 

  36. Esmaeili A, Ghobadianpour S (2016) Vancomycin loaded superparamagnetic MnFe2O4 nanoparticles coated with PEGylated chitosan to enhance antibacterial activity. Int J Pharm 501:326–330

    Article  Google Scholar 

  37. Li P, Li J, Wu C, Wu Q, Li J (2005) Synergistic antibacterial effects of β-lactam antibiotic combined with silver nanoparticles. Nanotechnology 16:1912–1917

    Article  Google Scholar 

  38. Shahverdi AR, Fakhimi A, Shahverdi HR, Minaian S (2007) Synthesis and effect of silver nanoparticles on the antibacterial activity of different antibiotics against Staphylococcus aureus and Escherichia coli. Nanomedicine 3:168–171

    Google Scholar 

  39. Hwang IS, Hwang JH, Choi H, Kim KJ, Lee DG (2012) Synergistic effects between silver nanoparticles and antibiotics and the mechanisms involved. J Med Microbiol 61:1719–1726

    Article  Google Scholar 

  40. Kooti M, Gharineh S, Mehrkhah M, Shaker A, Motamedi H (2015) Preparation and antibacterial activity of CoFe2O4/SiO2/Ag composite impregnated with streptomycin. Chem Eng J 259:34–42

    Article  Google Scholar 

  41. Etayash H, Norman L, Thundat T, Stiles M, Kaur K (2014) Surface-conjugated antimicrobial peptide leucocin a displays high binding to pathogenic gram-positive bacteria. ACS Appl Mater Interfaces 6:1131–1138

    Article  Google Scholar 

Download references

Acknowledgements

This work was supported by Grants from the National Natural Science Foundation of China (No 81,230,089), and Beijing Municipal Science & Technology Commission (No. Z161100000116040).

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    Authors and Affiliations

    1. College of Life Sciences & Bio-Engineering, Beijing University of Technology, Beijing, 100124, People’s Republic of China

      Chongwen Wang & Shengqi Wang

    2. Anhui Medical University, Hefei, 410073, People’s Republic of China

      Shengping Xu & Shengqi Wang

    3. Beijing Institute of Radiation Medicine, Beijing, 100850, People’s Republic of China

      Chongwen Wang, Shengping Xu, Kehan Zhang, Min Li, Qingjun Li, Rui Xiao & Shengqi Wang

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    1. Chongwen Wang
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    Correspondence to Rui Xiao or Shengqi Wang.

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    Chongwen Wang and Shengping Xu contributed equally to this work.

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    Wang, C., Xu, S., Zhang, K. et al. Streptomycin-modified Fe3O4–Au@Ag core–satellite magnetic nanoparticles as an effective antibacterial agent. J Mater Sci 52, 1357–1368 (2017). https://doi.org/10.1007/s10853-016-0430-6

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