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Surface characteristics and blood compatibility of PVDF/PMMA membranes

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Abstract

Poly(vinylidene fluoride) (PVDF)/poly(methyl methacrylate) (PMMA) membranes have important applications as biomaterials. In this study, PVDF/PMMA with varying ratios is blown into membranes, the surface property and blood compatibility of which are thoroughly investigated. Membrane surface characteristics including composition and topography exert considerable influence on the blood compatibility. Introduction of PMMA disturbs PVDF crystallization, however, favors the β phase crystal formation. PVDF content, crystallization ability, and surface enrichment have decisive effects on the membrane surface composition. Meanwhile, with increased PMMA fraction, the membrane surface roughness is also increased, and subsequently results in decreased hemocompatibility. While the membranes with PMMA content lower than 30 wt% show good blood compatibility, those with higher PMMA fraction exhibit obvious platelet adhesion to the surface. Thermal annealing promotes the formation of β phase PVDF and generates much smoother surface, thus endowing the membranes with greatly enhanced blood compatibility. These results show the prospect for optimization of processability, surface property, and blood compatibility of PVDF/PMMA membranes through facile modulation of PMMA content and fabrication process.

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Acknowledgements

This work was financially supported by the “12th 5-year” National Key Technologies R&D Program of China (2011BAE08B00), the National Science Foundation of China (21104044), the Ph.D. Programs Foundation of Ministry of Education of China (20110073120040), and the Shanghai Leading Academic Discipline Project (No. B202). W. Z. Yuan thanks the Start-up Foundation for New Faculties of Shanghai Jiao Tong University. The authors thank Dr. Limin Sun from Instrumental Analysis Center of SJTU for the XPS analysis.

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Authors and Affiliations

  1. School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China

    Fei Ai, Hong Li, Wang Zhang Yuan, Xiaoyong Chen, Libin Yang, Junhong Zhao & Yongming Zhang

  2. Shanghai Veterinary Institute, Chinese Academy of Agricultural Sciences, Shanghai, 200241, China

    Quan Wang

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  1. Fei Ai
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  2. Hong Li
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  3. Quan Wang
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  4. Wang Zhang Yuan
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  5. Xiaoyong Chen
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Correspondence to Wang Zhang Yuan or Yongming Zhang.

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Ai, F., Li, H., Wang, Q. et al. Surface characteristics and blood compatibility of PVDF/PMMA membranes. J Mater Sci 47, 5030–5040 (2012). https://doi.org/10.1007/s10853-012-6379-1

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  • DOI: https://doi.org/10.1007/s10853-012-6379-1

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