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The influences of poly(lactic-co-glycolic acid) (PLGA) coating on the biodegradability, bioactivity, and biocompatibility of calcium silicate bioceramics

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Abstract

Calcium silicate (CaSiO3) bioceramics and polyesters have complementary qualities as potential bone substituted materials. In this study, sintered CaSiO3 bioceramics were prepared and coated with poly(lactic-co-glycolic acid) (PLGA), and the influences of the PLGA coating on the degradation, hydrophilicity, bioactivity, and biocompatibility of CaSiO3 ceramics were investigated. The results showed that the degradation rate was reduced, while hydrophilicity was decreased with the increase of the polymer coating. In addition, the polymer coating resulted in a decrease of the alkaline pH value during the degradation of the ceramics, which indicated an increase of the cell biocompatibility, confirmed by the attachment and proliferation of rMSCs on the surface of the polymer-coated ceramics. Furthermore, the apatite-forming ability of the PLGA-coated CaSiO3 bioceramics was maintained. This study suggested that the coating with PLGA might be a useful method to improve the integrative properties of CaSiO3 bioceramics for applications in bone regeneration and bone tissue engineering.

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Acknowledgement

This study was supported by the Natural Science Foundation of China (Grant no. 30730034, 30900299), Science and Technology Commission of Shanghai Municipality (Grant no. 09JC1415500 09JC1409200), and Chinese Academy of Sciences for Key Topics in Innovation Engineering (Grant no. KGCX2-YW-207).

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Authors and Affiliations

  1. State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Dingxi Road, Shanghai, 200050, People’s Republic of China

    Lang Zhao, Kaili Lin, Meili Zhang & Jiang Chang

  2. Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu, 610041, People’s Republic of China

    Chengdong Xiong

  3. Zhejiang Apeloa Jiayuan Biomedical Materials Co. Ltd, Hengdian Industrial Zone, Dongyang Zhejiang, 322118, China

    Yihong Bao & Xiubing Pang

Authors
  1. Lang Zhao
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  2. Kaili Lin
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  3. Meili Zhang
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  4. Chengdong Xiong
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  5. Yihong Bao
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  6. Xiubing Pang
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  7. Jiang Chang
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Correspondence to Jiang Chang.

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Zhao, L., Lin, K., Zhang, M. et al. The influences of poly(lactic-co-glycolic acid) (PLGA) coating on the biodegradability, bioactivity, and biocompatibility of calcium silicate bioceramics. J Mater Sci 46, 4986–4993 (2011). https://doi.org/10.1007/s10853-011-5416-9

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  • DOI: https://doi.org/10.1007/s10853-011-5416-9

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